Gene Editing 101: 2018 Edition
Errors in the genetic code can be devastating to an organism if they occur in genes that influence cell survival or proliferation. These mutations can give rise to genetic diseases that severely impact a person’s health and, in some cases, prove lethal. It makes sense, therefore, that researchers would be keen to identify mechanisms that allow us to directly and selectively alter genomic sequences at will, enabling us to repair these types of mutations before they can cause disease.
Last year, we brought you the 2017 Edition of the Gene Editing 101, which introduced you to some of the techniques being used by researchers and how they could be used to further science and help patients. Since that book was published, the field has seen a number of advancements, from human embryonic engineering in the UK and Sweden, all the way to one case of in vivo gene editing in a human patient. Now, we’re giving you a new edition of the 101 to bring you up to speed on everything that has changed in the last 12 months.
This guide will discuss the gene editing tools currently available and how they can be used to manipulate genomic sequences, as well as the real world applications that put these tools to use. With help from our sponsors and collaborators, we have tried to bring you a clear, unbiased guide of gene editing. As before, this e-book is not intended to act as a wet lab guide for designing your experiments, but instead hopes to introduce you to the techniques available and how they can be used to improve human health and genomic understanding.
We hope that you find this guide to be interesting and, most importantly, useful.