Webinar

Improved Methods for CRISPR Homology-Directed Repair Using Alt-R HDR Enhancer and ssDNA Donors with Optimized Design

20 August 2019

CRISPR-Cas proteins introduce double-stranded breaks (DSBs) at targeted genomic loci. These are repaired by endogenous cellular pathways such as non-homologous end joining (NHEJ) and homology-directed repair (HDR). Providing a ssDNA template during repair allows researchers to introduce a desired mutation precisely, by utilizing the HDR pathway. However, rates of HDR are often low compared to […]

12 June 2019

New Approaches to the Old Hunt for NASH Therapies

Non-Alcoholic Steatohepatitis (NASH) is the most severe form of non-alcoholic fatty liver disease (NAFLD). The global prevalence of NAFLD is as high as one billion and is the most common cause of chronic liver disease, affecting between 80 and 100 million in the U.S., among whom nearly 25% progress to NASH. NASH is characterized by […]

28 May 2019

Enabling Distributed Clinical Genomics Operations, Powered by IBM Aspera and BlueBee

Advancements in sequencing technology and per sample cost reductions are driving rapid adoption of NGS by labs all over the world. Complementary software solutions are a critical enabler for raw data processing and biological discovery, and new cloud-based platforms provide scalability and ease of use. In this webinar, learn how IBM Aspera and BlueBee offer […]

29 October 2018

Maize genome complexity traversed with Oxford Nanopore technology

  Maize is one of the most economically important crops globally and much effort has been spent generating the high quality B73 reference genome. However, the 10 chromosome, 2.3 gigabase (Gb) B73 reference genome was a substantial challenge due to the fact it is comprised of 85% transposable elements, 75% of which are long terminal […]

25 September 2018

Human genome sequencing on PromethION: characterization of structural variants and repetitive regions

  At the VIB-UAntwerp Center for Molecular Neurology, we apply sequencing technologies to elucidate the genetic etiology of neurodegenerative brain diseases such as Alzheimer Disease and Frontotemporal Dementia. Structural variation and repetitive regions are insufficiently characterized using currently dominant short-read sequencing technologies. Long-read sequencing on the Oxford Nanopore PromethION has the potential for a comprehensive […]

19 April 2018

Drowning in TCGA Data: How to Keep Your Head Above Water

To fully benefit from the vast quantities of data from TCGA, tools for easy data visualisation and analysis must be developed for use of the non-computational scientist. Our panel of experts discuss TCGA data and the tools needed to make sense of it.

25 August 2017

Simplified Genome Editing and Detection Workflows

In this webinar, you’ll learn how to increase editing efficiency by directly introducing S. pyogenes Cas9 ribonucleoproteins (RNPs) to cells through electroporation or lipofection.

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