Caught on Film: Mutating DNA
DNA mutations cause tumour cells to grow out of control, but they also generate variety that enables organisms to adapt to their environments and evolve. Until now, biologists have only had crude methods for estimating the average rates and effects of mutations. But in a new study, biophysicists have documented individual mutations as they happen in bacterial cells.
These changes occur at about the same rate over time—as opposed to in bursts—and only about 1% are deadly, the researchers report today in Science. Moreover, all bacteria in a given strain seem to have about the same mutation rate—about one mutation per 600 hours in normal bacteria, and about 200 mutations per 600 hours in bacteria engineered to mutate at a faster rate—they note.
To see the mutations, the team built 1000 microscopic channels into a computerlike chip and placed a single bacterial cell at the closed end of each the channel, along with plenty of nutrients to survive… Elizabeth Pennisi explains in more detail over at Sciencemag.