Heating solid tumours during CAR-T cell therapy could increase change of success, researchers from the UCLA Jonsson Comprehensive Cancer Center have found. Combining a heating technique called photothermal ablation with the infusion of CAR-T cells suppressed melanoma tumor growth for up to 20 days in mice.
Harvard College researchers have announced that more than 13,000 genetic alterations have been made to a single cell using CRISPR technology. This work is designed to edit genomes at a much larger scale than currently possible.
Oncology and precision medicine company Strata Oncology has announced the launch of its expanded StrataNGS test 3.0 for patients with advanced cancer. The test analyses 500 genes for three particular immunotherapy biomarkers, microsatellite instability (MSI), tumor mutational burden (TMB) and PD-L1, to better inform use of precision treatments.
Pharma giant Biogen and its Japanese partner Eisai have made the decision to halt two phase 3 trials of aducanumab, a drug created to slow Alzheimer’s by targeting brain-destroying beta-amyloid fragments. An independent monitoring committee decided that the drug was unlikely to benefit patients compared with a placebo.
Microsoft has created the first ever “DNA drive”, a program which can encode digital information into DNA and vice versa. The prototype managed to store and hold only the word “hello”, taking 21 hours to complete the process due to the slow chemical reactions which writing DNA involves.
For the first time, CRISPR-Cas9 has been combined with electronic graphene transistors to create a new handheld device which can detect specific mutations in the genome within minutes. The device can be used to quickly diagnose genetic disorders and diseases or determine the accuracy of gene-editing techniques.
Scientists from the University of California have announced a possible alternative option to electronic eye implants for those who have lost their sight: gene therapy. Virus-delivered genes for green opsin gave blind mice sight enough to determine patterns on an iPad, they found, with the therapy possibly ready for clinical trials in three years’ time.
The scientists of seven nations have called for a halt to gene-editing experiments seeking to alter heritable traits in human babies.
Indiana University School of Medicine researchers have found blood-based genetic markets of psychological stress which could lead to better diagnostics for post-traumatic stress disorder (PTSD), and bring forward new drug development leads.
Oxford Nanopore has made its Flongle starter packs available to purchase, following an early-access testing programme. The Flongle machine allows for smaller, on-demand DNA sequence testing at low cost.
Commercial DNA-analysing company 23andMe is looking to launch a new DNA assessment to help individuals discover their risk of developing type 2 diabetes. Several million customers will receive the information over the coming weeks.
A number of mice have been cured entirely of lupus by a CAR-T treatment which wipes out the immune system’s B cells by spotting the CD19 protein marker which nearly all B cells carry.
Researchers at Cold Spring Harbor Laboratory have created a list of genetic “usual suspects” from a computational analysis of 635 datasets across around 27,000 genetic samples.
A second individual has experienced sustained remission from HIV after their treatment ended, scientists from the University of Central London and Imperial College have found.
Biogen has announced it will acquire Nightstar Therapeutics for around $800m, providing the pharma giant with a pipeline of gene therapy candidates for ophthalmology.