Scientists are looking for models of ageing to help determine the causes of many age-related diseases. By using Labradors, the researchers from the University of California have demonstrated a new model for ageing that can be applied to other mammalian species and provide insights into our own genome.
The rise of antimicrobial resistant malaria, especially across Asia, has caused great concern and a hunt for new drugs and treatment. A collaborative group across Europe have systematically deleted genes from Plasmodium berghei and uncovered 7 metabolic pathways crucial for the life cycle of the parasite.
One year on from the birth of world’s first CRISPR-edited babies in China, Jennifer Doudna, writes in Science what this and the ensuing controversy has meant for the field and society’s perception of the technology, as well as to outline what should be done next.
France has continued to ban people from ordering commercial DNA kits as part of the country’s Bioethics laws. These laws were widely expected to be relaxed and DNA Pass, an advocacy group, are increasing pressure to get these tests legalized.
Two confirmed cases this week of Pneumonic plague in China have local and international health agencies on high alert. A middle-aged couple are being treated in Beijing for the most severe form of the infection that has afflicted humanity since the Bronze Age. The bacterium Yersinia pestis can cause three distinct disease manifestations dependent on the […]
In an exciting new development, researchers have now developed a CRISPR-Cas9 system complexed with Chemical Epigenetic Modifiers (CEMs) that allowed dose-dependent activation of gene expression.
A new version of the CRISPR-Cas9 protein has been developed that can increase the targeting efficiency of the gene editing process. Currently the CRISPR Cas-9 system is the most widely used gene editing technique. However, concerns about CRISPR editing genes other than the ones it is targeted to have hindered its introduction into gene-therapy treatments […]
Primary tumour cells that have been starved of oxygen have been shown to have a survival advantage when spreading to different parts of the body to form new tumours. Over 90% of solid tumours are oxygen deprived. Known as hypoxia, this is associated with poorer prognosis for patients. This was thought to be due to […]
Self-destructing mitochondria could be the initiation step for a range of neurogenerative diseases, new research shows. Mitochondrial dysfunction has been observed in the early stages of ALS, a neurogenerative disease that affects voluntary muscle movement. The symptoms of ALS are caused by the disintegration of the upper motor neurons of the brain, which is often […]
Vitamin D has been shown to make melanoma cells less aggressive by interfering in a key signaling pathway that promotes cancer cell growth. Melanoma is a form of skin cancer which can be initiated by genetic damage from sun exposure. Melanoma patients are therefore encouraged to reduce their sun exposure to mitigate any further damage. […]
A protein that promotes the metastasis to the brain of breast, lung and other cancers has been identified. When cancer cells break off from their initial tumour they can spread throughout the body and invade other organs to form new tumours, in a process known as metastasis. Although metastatic tumours cause 90% of deaths in […]
We earlier highlighted the most important takeaways from the Genomics England Research Conference, including how the UK will work to build on its status as a world leader in genomics. We also wanted to put a spotlight on the exciting research that is using the data from the 100,000 Genomes Project. Here are Front Line […]
A mutation in one gene has been found to protect people from the onset of type 2 diabetes. Type 2 diabetes is caused by the inability of the body to regulate its blood sugar levels, as the cells are unable to produce or respond to the hormone insulin. Type 2 diabetes affects over 400 million […]
Genomics England and others offer a compelling vision for genomics in the UK and beyond The first Genomics England Research conference took place yesterday at the Central Hall Westminster in London. Front Line Genomics were lucky enough to have tickets, and what a fantastic and utterly unique event it was. The idea of the conference […]
Dental stem cells have successfully been differentiated into milk producing mammary gland cells, which could hold applications for reconstructive breast surgery. Researchers at the University of Zurich (UZH) were able to show that dental epithelial stem cells can, under the right conditions, form non-dental tissues, namely mammary glands in female mice. Dental epithelial stem cells […]