Ageing

Shorter Telomeres & Obesity Association Found in Children

A study published in Scientific Reports examined nearly 1,400 mother-child pairs from a multi-centre European birth cohort and found that childhood obesity was associated with shorter telomeres. Telomere length is a useful biomarker of biological ageing, as shorter telomeres are associated with a wide range of diseases. These encompass cancer, premature ageing, and obesity.

New Alzheimer’s Risk Variant Identified

Alzheimer’s Disease is a devastating neurological condition affecting 24 million people worldwide. It is the most frequent form of dementia with a heritable risk that is not wholly understood. A study published in the Journal of Neuropathology & Experimental Neurology has identified a new risk gene that was previously overlooked.

The New Way to Age Your Dog (and People)

Scientists are looking for models of ageing to help determine the causes of many age-related diseases. By using Labradors, the researchers from the University of California have demonstrated a new model for ageing that can be applied to other mammalian species and provide insights into our own genome.

Biogen to Seek Approval for First Alzheimer’s Drug

In a major shake-up of the pharmaceutical market, Biogen announced that it intends to seek approval from the FDA for its Alzheimer’s drug aducanumab. This follows their earlier announcement that the two clinical trials evaluating the effectiveness of the drug in patients had been discontinued. However, Biogen state that data from additional patients in the […]

Damping Down Brain Activity Could Extend Lifespan

Reducing brain activity could extend human lifespan, new research shows. Although it is known that gene expression changes as people age, the mechanisms that extend human lifespan are not well understood. However, new research has revealed that differences in brain activity could be the reason some people live longer than others. Extended longevity in humans […]

Fish Can Conserve Memories Across Generations

The myth of the goldfish’s three second memory has long prevailed in popular culture. However, new research has suggested that unlike humans, fish are able to conserve memories over generations using epigenetic mechanisms. Epigenetic modifications can change the expression of DNA without changing the DNA code itself. Often this is in the form of DNA […]

Alternative Cause of Alzheimer’s Discovered

Alzheimer’s has previously been understood to be caused by a build up of protein plaques in the brain. However, new research has revealed that alternative metabolic pathways in the brain may be more integral to the formation of the disease. The plaques are formed by proteins known as beta-amyloid and tau. As Alzheimer’s progresses the […]

Genetic Mutation Significantly Increases Fruit Fly Lifespan

Fruit flies with a certain genetic mutation have significantly longer lifespans and better resistance to stresses than flies without the mutation. Fruit flies share a significant proportion of their genes with humans, making them good models to study human diseases and ageing. As the fruit flies usually live for about two months their lifespan is […]

Contributory Cause of Cell Ageing Discovered

Cells discontinuing nucleotide synthesis could be a key factor in ageing, new research has revealed. Understanding this process could enable treatments that ensure healthier ageing. The process by which cells become unable to replicate after a certain number of divisions is known as senescence. As cell division is essential the body’s repair processes, senescence can […]

Gene Discovery Explains Failure of Alzheimer’s Drugs

A gene discovery has explained why current Alzheimer’s drugs don’t work for lots of patients, and why so many new drugs fail in clinical trials. The acetylcholine receptor α7nAChR has long been a target of interest for Alzheimer’s drugs. The neurotransmitter acetylcholine is involved in memory and learning processes. Despite acetylcholine being linked to the […]

RNA Key to Anti-Ageing Skincare

Scientists have found that RNA production is behind the regenerative affects of laser skincare treatments. Laser treatments are a widespread cosmetic procedure to make skin appear younger and healthier. The laser slightly damages the skin cells, forcing them to repair themselves. After the repair process, the skin looks younger, but until recently the mechanism to […]

Healthy Lifestyle can Reduce Genetic Risk for Dementia

A study has shown that you can reduce your risk of getting dementia by adapting a healthy lifestyle, regardless of your genetic pre-disposition. Genetic factors can increase a person’s likelihood of getting dementia, but until now it was not known if making lifestyle changes could reduce this risk. 196,383 individuals above 60 years of age […]

New Gene Linked to Healthy Ageing in Worms

A gene has been identified in worms that improves their health, but not their lifespan, as they age. Maintaining quality of life is becoming a focus in healthcare for the elderly, as people that live to the same age do not necessarily have the same quality of life. Some maintain both their movement and cognitive […]

Species Lifespan Predicted by Rate of Telomere Shortening

New research has indicated that a species’ lifespan can be predicted by the rate of telomere shortening but not by the initial telomere length, as previously thought. Telomeres are repetitive sequences of DNA nucleotides found at the end of chromosomes. They protect the chromosome from degradation during cell division. As species age, the length of […]

Alzheimer’s-Linked Gene Could be Re-shuffling its Own DNA

APP, the gene responsible for making beta-amyloid in the brain, may be able to reshuffle its own DNA, scientists from Sanford Burnham Prebys Medical Discovery Institute in California have claimed. This development could explain why most drugs to treat Alzheimer’s, which are designed to remove beta-amyloid protein build-ups in the brain, have proven ineffective in clinical trials.