Researchers have genetically modified stem cells inside the bodies of mice for the first time, in a study that could lead eventually to new potential for stem cell therapies. The study also shows potential for studying genetically-edited stem cells within the body, rather than in the lab.
University of Maryland scientists have genetically modified a fungus to produce a toxin fatal to mosquitoes, in order to reduce the malaria death toll they currently cause. An out-of-lab trial destroyed a mosquito population almost entirely within 45 days, leading some to criticise the work as “too dangerous” for the real world.
Scientists at the Institute of Neuroscience (ION) in China have reportedly used gene-editing technology to disable a certain gene vital to sleep-cycle in macaque monkeys. This prototype could create populations of genetically identical monkeys to allow scientists to better study the mechanisms of complex human disorders.
A new high-throughput sequencing technique created by scientists at the University of Chicago will uncover how naturally occurring microbiomes respond to real-world conditions and diets. The technique, outlined in Nature Communications, directly analyses transfer RNA (tRNA) to give a clear picture of microbial communities’ reactions to environment changes including temperature variations and nutrient availability.
A modified version of CRISPR has been used to reverse genetic obesity in two different mouse models without editing any genes. The technique uses the guidance system in CRISPR to target certain genetic sequences and amplifies existing gene activity to ramp up protein production.
Personalised tumour-detecting cells from adult skin cells have been used to shrink brain tumours in mice by up to 5%, scientists have revealed. While the strategy has not yet been fully tested in people, it could in the future give doctors the ability to develop a custom treatment for certain cancer types.
Baboons can live for up to 195 days with hearts taken from pigs and genetically engineered to avoid extreme immune reactions, three times longer than previous attempts, according to a report published in Nature journal.
Researchers at the Chinese Academy of Sciences have used two female mice to create offspring which subsequently went on to have healthy children of their own. While similar offspring were produced from two male mice, they did not survive for longer than a few days.
Researchers from the University of Alabama have identified a method by which it is possible to reduce the signs of ageing, such as wrinkles and hair loss, in mice.
Scientists have discovered a naturally occurring disease in monkeys that mimics a deadly childhood neurodegenerative disorder in people — a finding that holds promise for developing new gene therapies to treat Batten disease.
Researchers have found a genetic material related to the Ebola Virus in mouse-eared bats thats remained largely unchanged for over 18 million years. The study sheds light on the gene’s possible function in bats, suggesting that it may play a role in regulating the immune system’s response to threats.
Prenatal gene therapy has been used to prevent acute neuronopathic Gaucher’s disease, however this approach is using viruses to deliver normal copies of genes.
A new type of zebrafish that produces fluorescent tags in migratory embryonic nerve precursor cells could help researchers find the origins of the third-most common pediatric cancer in the U.S.