Bioinformatics

As the volume and depth of genomic data grows, bioinformaticians are translating genomic data into interpretable patterns leading to new biological insight.

Advances in Improving HDR Efficiency for CRISPR Experiments

Despite vast progress in leveraging the CRISPR-Cas9 system for genome manipulation, bottlenecks still remain. Overcoming these bottlenecks is critical to ensure the efficacy of this technology in a clinical context. Several engineering approaches involve inducing a double -stranded break (DSB) to introduce new mutations, which are then repaired by the endogenous cellular machinery. The two […]

Scientists Engineer Proteins into Never-Ending Patterns

Scientists have engineered proteins to form fractal geometric shapes with never-ending patterns, closely resembling those found in nature. The protein patterns could have applications in next-generation biomaterials. Fractal geometric shapes make extremely useful biomaterials as they have large surface to volume ratios, allowing rapid exchange of materials. This makes them ideal for applications both in […]

Colour Changing Tattoos Can Sense Biomarkers

Scientists have developed tattoos that change colour depending on the interstitial fluid concentration of key biomarkers. The development is a step towards developing quicker diagnostics. The biomarkers studied were pH, glucose and albumin. Variation of blood pH can be indictive of a range of health conditions and glucose sensing is extremely useful for monitoring diabetes. […]

Digital DNA: Hacking DNA Databases – An Interview with Peter Ney

The Digital DNA series will explore the role of large-scale genetic testing in science, industry and society. We aim to understand both the benefits and risks of this emerging technology and see what the future may hold. In the first of our Digital DNA series, we talked to Dr. Peter Ney, a researcher in the […]

A Guide to Biodata: Analysis, Integration and Management

It has now been 16 years since the Human Genome Project sequenced the first ever human genome: in that time, as has been mentioned in previous editions of this report, more than 500,000 genomes have been sequenced, generating enough data to drastically raise computational resource usage and create a need for rapid innovation to offset […]

How to Recruit a High-Performing Apprentice: Anglia Ruskin Panel Event

In September 2019, Anglia Ruskin University’s (ARU’s) Cambridge campus will begin the first year of its new – and currently unique in the UK – Data Scientist Degree Apprenticeship for the bioinformatics profession. Ahead of this, ARU and the Wellcome Sanger Institute have set up a “Lunch and Learn” panel event for hiring managers and talent acquisition specialists, looking at how they can best recruit and support top apprentices.

Maize genome complexity traversed with Oxford Nanopore technology

  Maize is one of the most economically important crops globally and much effort has been spent generating the high quality B73 reference genome. However, the 10 chromosome, 2.3 gigabase (Gb) B73 reference genome was a substantial challenge due to the fact it is comprised of 85% transposable elements, 75% of which are long terminal […]

GWAS Coming Of Age

There’s a fantastic editorial over in nature medicine that you should really take a look at, if you’re interested in finding out more about where the future of GWAS might be heading.

What Could You Do With 10,000 Immunomes?

A database of normal human immunity has been created by scientists at UC San Francisco, creating an instant comparison group to let researchers use in studies of the immune system and immune dysfunction.