Bioinformatics

As the volume and depth of genomic data grows, bioinformaticians are translating genomic data into interpretable patterns leading to new biological insight.

Alzheimer’s Disease Genetic Research Consortium Launched in New York

York Governor, Andrew Cuomo, announced legislation to launch a consortium of public and private research groups to investigate the genetics of Alzheimer’s disease. The five-year initiative, called the SUNY Curing Alzheimer’s Health Consortium, will analyse the genetics of 1 million people who suffer from or are at risk of developing Alzheimer’s disease over 5 years.

Interview with Dr Luigi Grassi, Informatics Scientist, AstraZeneca

FLG: Could you give us an introduction of yourself and the work you do? I’m Luigi Grassi and I’m an Informatics Scientist at AstraZeneca. I’m responsible for designing and performing bioinformatical analyses of the high throughput sequencing experiments we use to characterise stable cell lines expressing biotherapeutics. FLG: What motivated you to pursue a career […]

Butler: Analysing Genomes in the Cloud

Ask Jeeves may be a thing of the past as there’s a new butler in town. Specifically, one to serve your genomic data analysis needs. This week scientists from the European Molecular Biology Laboratory (EMBL) have unveiled a new computational tool to facilitate large-scale genomic analysis on the cloud. This, they say, will overcome stability […]

Genetic Cause of a Rare Type of Epilepsy Found

The cause of a rare type of familial epilepsy has been linked to two new gene mutations, as discovered by researchers from the Walter and Eliza Hall Institute. Published back-to-back in Nature Communications, Dr Mark Bennett, Dr Haloom Rafehi and Professor Melanie Bahlo from the Institute made this ground-breaking discovery as part of an international consortium.

Advances in Improving HDR Efficiency for CRISPR Experiments

Despite vast progress in leveraging the CRISPR-Cas9 system for genome manipulation, bottlenecks still remain. Overcoming these bottlenecks is critical to ensure the efficacy of this technology in a clinical context. Several engineering approaches involve inducing a double -stranded break (DSB) to introduce new mutations, which are then repaired by the endogenous cellular machinery. The two […]

Scientists Engineer Proteins into Never-Ending Patterns

Scientists have engineered proteins to form fractal geometric shapes with never-ending patterns, closely resembling those found in nature. The protein patterns could have applications in next-generation biomaterials. Fractal geometric shapes make extremely useful biomaterials as they have large surface to volume ratios, allowing rapid exchange of materials. This makes them ideal for applications both in […]

Colour Changing Tattoos Can Sense Biomarkers

Scientists have developed tattoos that change colour depending on the interstitial fluid concentration of key biomarkers. The development is a step towards developing quicker diagnostics. The biomarkers studied were pH, glucose and albumin. Variation of blood pH can be indictive of a range of health conditions and glucose sensing is extremely useful for monitoring diabetes. […]

Digital DNA: Hacking DNA Databases – An Interview with Peter Ney

The Digital DNA series will explore the role of large-scale genetic testing in science, industry and society. We aim to understand both the benefits and risks of this emerging technology and see what the future may hold. In the first of our Digital DNA series, we talked to Dr. Peter Ney, a researcher in the […]

A Guide to Biodata: Analysis, Integration and Management

It has now been 16 years since the Human Genome Project sequenced the first ever human genome: in that time, as has been mentioned in previous editions of this report, more than 500,000 genomes have been sequenced, generating enough data to drastically raise computational resource usage and create a need for rapid innovation to offset […]

How to Recruit a High-Performing Apprentice: Anglia Ruskin Panel Event

In September 2019, Anglia Ruskin University’s (ARU’s) Cambridge campus will begin the first year of its new – and currently unique in the UK – Data Scientist Degree Apprenticeship for the bioinformatics profession. Ahead of this, ARU and the Wellcome Sanger Institute have set up a “Lunch and Learn” panel event for hiring managers and talent acquisition specialists, looking at how they can best recruit and support top apprentices.

Maize genome complexity traversed with Oxford Nanopore technology

  Maize is one of the most economically important crops globally and much effort has been spent generating the high quality B73 reference genome. However, the 10 chromosome, 2.3 gigabase (Gb) B73 reference genome was a substantial challenge due to the fact it is comprised of 85% transposable elements, 75% of which are long terminal […]