Clinical genomics

Efficiently translating genomic research into the clinic is one of the most important steps in the development of the field. The clinic is where we will see things come to fruition.

CRISPR Identifies Cancer Drug Targets

A team from the Wellcome Trust Sanger Institute and Broad Institute have used CRISPR-Cas9 to identify key genes required for cancer survival. Over 18,000 genes from 30 different cancer types were screened, a computational framework then developed to prioritise the 600 most promising drug development targets.

Effects of Poverty Make Their Mark on 1,500 Genes in the Body

A study conducted by Northwestern University researchers has found that long-term poverty can be “embedded” across the genome. Lower socioeconomic status was found to be associated with levels of DNA methylation, a key epigenetic mark that can influence expression, across more than 1,500 genes.

More Than 13,000 Genetic Edits Made to Single Cell

Harvard College researchers have announced that more than 13,000 genetic alterations have been made to a single cell using CRISPR technology. This work is designed to edit genomes at a much larger scale than currently possible.

Biogen’s Lead Alzheimer’s Drug Falls Down at Phase Three Trials

Pharma giant Biogen and its Japanese partner Eisai have made the decision to halt two phase 3 trials of aducanumab, a drug created to slow Alzheimer’s by targeting brain-destroying beta-amyloid fragments. An independent monitoring committee decided that the drug was unlikely to benefit patients compared with a placebo.

Researchers Identify PTSD Blood Biomarkers

Indiana University School of Medicine researchers have found blood-based genetic markets of psychological stress which could lead to better diagnostics for post-traumatic stress disorder (PTSD), and bring forward new drug development leads.

Second Set of “Semi-Identical Twins” Identified

Twins born in Australia have become the second-ever-identified pair of “semi-identical” twins, and the first to be detected before they were born. Such cases come about when twins receive 100% identical genes from their mother, but not from their father.

First Common Risk Genes for Autism Discovered

Researchers from the Broad Institute in the US and Danish iPSYCH project have discovered the first common genetic risk variants for autism and uncovered genetic differences in clinical subgroups of autism.

How to Recruit a High-Performing Apprentice: Anglia Ruskin Panel Event

In September 2019, Anglia Ruskin University’s (ARU’s) Cambridge campus will begin the first year of its new – and currently unique in the UK – Data Scientist Degree Apprenticeship for the bioinformatics profession. Ahead of this, ARU and the Wellcome Sanger Institute have set up a “Lunch and Learn” panel event for hiring managers and talent acquisition specialists, looking at how they can best recruit and support top apprentices.