Clinical genomics

Efficiently translating genomic research into the clinic is one of the most important steps in the development of the field. The clinic is where we will see things come to fruition.

Sir John Chisholm and Professor John Mattick to Leave Genomics England

Genomics England has announced the appointment of Jonathan Symonds CBE as its new Chair to replace Sir John Chisholm, who leaves the organisation on 29 January 2019. Genomics England’s CEO, Professor John Mattick, is also stepping down to be temporarily replaced by Genomic England’s current Chief Scientist, Professor Mark Caulfield.

“Switch Mechanism” in CRISPR Could Prevent Unwanted Side Effects

A new study published in Cell magazine and co-authored by CRISPR pioneer Jennifer Doudna has suggested a potential solution to the unwanted side-effects of using CRISPR in the body. The study details using a “switch” mechanism which could keep the Cas9 enzyme turned off until it reaches its target site.

Genetics Unzipped: A New Science Podcast Exploring the World of Genes, Genomes and DNA

Genetics Unzipped, a new fortnightly podcast from the UK Genetics Society, has launched ahead of the society’s centenary celebrations throughout 2019. Presented by award-winning science writer and former Naked Genetics/Naked Scientists podcast host Kat Arney and produced by First Create The Media, Genetics Unzipped will bring you a wide range of stories from the world of genetics, genomics and DNA.

New tRNA Sequencing Method Uncovers Microbiome Activity

A new high-throughput sequencing technique created by scientists at the University of Chicago will uncover how naturally occurring microbiomes respond to real-world conditions and diets. The technique, outlined in Nature Communications, directly analyses transfer RNA (tRNA) to give a clear picture of microbial communities’ reactions to environment changes including temperature variations and nutrient availability.

Injectable RNA Treatment Helps Cure LCA Blindness

Data has shown the success of a new therapy to combat Leber congenital amaurosis (LCA), one of the leading causes of blindness in children, in LCA patients with CEP290 mutations. CEP290 acts as a barrier between two compartments of photoreceptor cells in the eye which convert light into signals, creating vision. Blindnesses caused by CEP290 […]

Hepatitis Drug Could Help Delay Progress of ALS

Telbivudine, a drug currently in use for treating patients with hepatitis, could be of use in significantly slowing the progression of Amyotrophic lateral sclerosis (ALS), scientists from the University of Alberta have announced.

No-Incision CRISPR Reduces Genetic Obesity in Mice

A modified version of CRISPR has been used to reverse genetic obesity in two different mouse models without editing any genes. The technique uses the guidance system in CRISPR to target certain genetic sequences and amplifies existing gene activity to ramp up protein production.

International Study Finds 11 New Epilepsy Genes

Eleven new genes associated with epilepsy have been discovered by an international team of scientists, advancing knowledge of the underlying causes of the condition and potentially helping in the development of new treatments.