Helen C. O’Neill has explored how the global reaction to the birth of genome-edited twins in 2018 echoed the condemnation surrounding the first successful use of in-vitro fertilisation (IVF) in 1978. Now regarded as a huge clinical success which has benefitted an estimated 16 million parents, at the time the development not only sparked moral outrage but led to political and legislative constraints.
Huge viruses with CRISPR-Cas and translational components have been described by researchers at the University of California, Berkeley – providing a possible new tool for genome editing of bacteria.
Bioengineers based in the US have designed a “DNA-binding editorial assistant” that will allow gene-editing technology, like CRISPR, to access previously inaccessible genes of interest. The new protein design can be used to open up areas of the DNA that are obscured by chromatin, which would improve CRISPR efficiency and aid in developing more precise gene-editing techniques to combat disease.
Researchers from the Cold Spring Harbor Laboratory (CSHL) and Memorial Sloan Kettering Cancer Center (MSK) have discovered that Acute Myeloid Leukaemia (AML) grows by taking advantage of the B6 vitamin to accelerate cell division. The findings could pave the way for a treatment that can stop cancer growth by manipulating the enzyme that pushes B6 to make proteins essential for cell division.
Scientists at Navega Therapeutics in San Diego, California have discovered a way to target DNA to stop pain signals being sent and eliminate pain. In an article published by Pharmafile, the treatment could be available in five years to help sufferers of chronic pain or with long-term pain problems.
In late 2018, the world was shocked by the news of the birth of the first CRISPR gene edited twin babies. Chinese biophysicist He Jiankui carried out an experiment to create babies with a natural resistance to HIV by editing the CCR5 gene, known to play a role in the immune response.
The first gene editing clinical trial sponsored by US companies has released data to STAT news showing promising results using a CRISPR based therapy. Sickle cell anaemia and beta thalassemia patients required no further treatments after one appointment.
One year on from the birth of world’s first CRISPR-edited babies in China, Jennifer Doudna, writes in Science what this and the ensuing controversy has meant for the field and society’s perception of the technology, as well as to outline what should be done next.
In an exciting new development, researchers have now developed a CRISPR-Cas9 system complexed with Chemical Epigenetic Modifiers (CEMs) that allowed dose-dependent activation of gene expression.
A new version of the CRISPR-Cas9 protein has been developed that can increase the targeting efficiency of the gene editing process. Currently the CRISPR Cas-9 system is the most widely used gene editing technique. However, concerns about CRISPR editing genes other than the ones it is targeted to have hindered its introduction into gene-therapy treatments […]
A new biomarker that can identify depression patients experiencing a lack of motivation could be used to tailor anti-depressant drugs to patients, depending on the specific symptoms of the disease they display. Depression is one of the most common psychiatric disorders in the world and affects about 9% of the US population. However, as less […]
A CRISPR encoded plasmid that causes Salmonella bacteria to make lethal cuts to its own genome could be a promising infection treatment to replace antibiotics. The gut microbiome is the ecosystem of the different types of bacteria that reside in the gut. Many gut infections are caused by one species of microbiome bacteria becoming much […]
A new gene editing tool known as Prime Editing has been developed that could reverse the harmful mutations in over 89% of genetic diseases. Building on the CRISPR Success Currently the CRISPR Cas-9 system is the most widely used gene editing technique. However, concerns about CRISPR editing genes, other than the ones it is targeted […]
CRISPR gives us the ability to precisely edit genes within cells, and the technique holds enormous potential for transforming the gene therapy space. However, concerns about CRISPR editing genes other than the ones it is targeted to have hindered its introduction into patient treatments. Known as off-target mutations, these unintended gene edits caused by CRISPR […]
Cancer cells are prone to disguising themselves from the immune system to avoid detection. However, a new system can pinpoint cancer cells to allow the immune system to eliminate the tumour. Immunotherapy is a cancer treatment that harnesses the body’s immune system to fight cancer cells. Although immunotherapies have completely transformed the cancer treatment landscape, […]