In late 2018, the world was shocked by the news of the birth of the first CRISPR gene edited twin babies. Chinese biophysicist He Jiankui carried out an experiment to create babies with a natural resistance to HIV by editing the CCR5 gene, known to play a role in the immune response.
The first gene editing clinical trial sponsored by US companies has released data to STAT news showing promising results using a CRISPR based therapy. Sickle cell anaemia and beta thalassemia patients required no further treatments after one appointment.
One year on from the birth of world’s first CRISPR-edited babies in China, Jennifer Doudna, writes in Science what this and the ensuing controversy has meant for the field and society’s perception of the technology, as well as to outline what should be done next.
In an exciting new development, researchers have now developed a CRISPR-Cas9 system complexed with Chemical Epigenetic Modifiers (CEMs) that allowed dose-dependent activation of gene expression.
A new version of the CRISPR-Cas9 protein has been developed that can increase the targeting efficiency of the gene editing process. Currently the CRISPR Cas-9 system is the most widely used gene editing technique. However, concerns about CRISPR editing genes other than the ones it is targeted to have hindered its introduction into gene-therapy treatments […]
A new biomarker that can identify depression patients experiencing a lack of motivation could be used to tailor anti-depressant drugs to patients, depending on the specific symptoms of the disease they display. Depression is one of the most common psychiatric disorders in the world and affects about 9% of the US population. However, as less […]
A CRISPR encoded plasmid that causes Salmonella bacteria to make lethal cuts to its own genome could be a promising infection treatment to replace antibiotics. The gut microbiome is the ecosystem of the different types of bacteria that reside in the gut. Many gut infections are caused by one species of microbiome bacteria becoming much […]
A new gene editing tool known as Prime Editing has been developed that could reverse the harmful mutations in over 89% of genetic diseases. Building on the CRISPR Success Currently the CRISPR Cas-9 system is the most widely used gene editing technique. However, concerns about CRISPR editing genes, other than the ones it is targeted […]
CRISPR gives us the ability to precisely edit genes within cells, and the technique holds enormous potential for transforming the gene therapy space. However, concerns about CRISPR editing genes other than the ones it is targeted to have hindered its introduction into patient treatments. Known as off-target mutations, these unintended gene edits caused by CRISPR […]
Cancer cells are prone to disguising themselves from the immune system to avoid detection. However, a new system can pinpoint cancer cells to allow the immune system to eliminate the tumour. Immunotherapy is a cancer treatment that harnesses the body’s immune system to fight cancer cells. Although immunotherapies have completely transformed the cancer treatment landscape, […]
Normally harmless fruit flies have been gene edited using CRISPR, with genes from the monarch butterfly, to make them poisonous to both their predators and humans. The monarch caterpillars feed on the toxic plant milkweed. When the caterpillars metamorphosise into butterfly’s they retain the milkweed toxins in their tissues, which make them poisonous to potential […]
An oligonucleotide treatment for muscular dystrophy has shown promising results in pre-clinical trials. It is estimated that the new treatment could be effective for over half of muscular dystrophy patients. Muscular dystrophy is a hereditary condition characterised by a progressive weakening and wasting of the muscles. It is caused by a malfunction in the gene […]
The gene editing technique CRISPR has been used successfully on reptiles for the first time, to produce four albino lizards. Although birds, mammals and fish have been successfully edited with CRISPR, reptiles have proved more challenging targets for the CRISPR/Cas-9 system due to the differences in their reproductive physiology. The brown anole lizard, Anolis sagrei, […]
A CRISPR therapy that attempted to cure a man of HIV has failed, but proved safe for the patient. The patient was diagnosed with HIV/AIDs and acute lymphoblastic leukemia. He was being treated with chemotherapy for the leukemia and anti-viral drugs for HIV, which reduce the amount of virus in the blood but do not […]
Front Line Genomics hosted the webinar Improved Methods for CRISPR Homology-Directed Repair Using Alt-R HDR Enhancer and ssDNA Donors with Optimized Design, which you can watch on demand for free here. The webinar described how to overcome some of the bottlenecks to using the CRISPR-Cas9 for genome manipulation and ensure its efficacy in a clinical […]