Front Line Genomics hosted the webinar Improved Methods for CRISPR Homology-Directed Repair Using Alt-R HDR Enhancer and ssDNA Donors with Optimized Design, which you can watch on demand for free here. The webinar described how to overcome some of the bottlenecks to using the CRISPR-Cas9 for genome manipulation and ensure its efficacy in a clinical […]
It has been less than a week since the landmark study into the genetics of same-sex sexual behaviour first broke and sparked debate across the twitterverse. There has been much disagreement amongst the scientific and LGBTQ+ communities alike, regarding whether this research should have been conducted at all. Conversely, many have praised the study for […]
Despite vast progress in leveraging the CRISPR-Cas9 system for genome manipulation, bottlenecks still remain. Overcoming these bottlenecks is critical to ensure the efficacy of this technology in a clinical context. Several engineering approaches involve inducing a double -stranded break (DSB) to introduce new mutations, which are then repaired by the endogenous cellular machinery. The two […]
A new technique that can store information in DNA, known as DOMINO, has been successfully developed by researchers at MIT. The future of biotechnology and biodata requires an effective method to store information in DNA. Just like a hard drive, the information should be readable, writable and able to be edited. Writable DNA information can […]
The first law to regulate the use of genome editing technology has been passed in California. Senator Ling Ling Chang authored the bill that requires sellers of gene therapy kits to include a label, and a notice prior to sale, stating that the CRISPR kits are not intended for self-administration. The bill is targeting ‘DIY […]
A CRISPR activation technique has been shown to improve the symptoms of muscular dystrophy disease in mice. Muscular dystrophy is a hereditary condition characterised by progressive weakening and wasting of the muscles. A specific type of muscular dystrophy is caused by mutations in the gene Lama2, which codes for the protein laminin. Mutations in the […]
The World Health Organisation (WHO) has released a statement calling for a stop to germline editing in humans. This is in light of recent controversial experiments in the field which emphasized patient safety concerns. Germline editing refers to the genome editing of reproductive cells. These changes are inheritable, and the technology has the potential to […]
A CRISPR technique has been used to identify genes in cells that enable them to survive infection of the Zika Virus. It is hoped that this development will lead to future treatments for Zika. Currently there is no vaccine or treatment specific to the Zika virus. If pregnant women contract the disease their unborn children […]
A CRISPR-based technique has been used in mice to ensure they give birth to exclusively female offspring. This has applications for selecting the sex ratio in livestock. Although offspring sex selection through genetic techniques has previously been achieved in fish and insects, this is the first successful attempt in mammals. Mammal offspring sex selection has […]
A new CRISPR-based method has managed to eliminate HIV in mice, for the first time potentially curing the lifelong illness of HIV/AIDs. Clinical trials will start next year to identify if the same method could be used to cure humans. HIV is a virus which attacks the immune cells in the body, leaving it […]
Inscripta has presented its scalable platform for benchtop digital CRISPR engineering, described as world first, at the 2019 Synthetic Biology: Engineering, Evolution & Design (SEED) conference. The technology, “CRISPR-enabled trackable genome engineering” or CREATE, is meant to remove certain limitations of CRISPR to allow for more wide-reaching research in the future.
Scientists at the Technical University of Dortmund have grown a type of tobacco containing 99.7% less nicotine. CRISPR was used to disable certain plant enzymes aiding in nicotine production, potentially creating a tobacco to help users quit smoking.
Russian biologist Denis Rebrikov has announced his intentions to produce further gene-edited babies, ignoring the scientific consensus that this should not be done until an ethical framework is constructed to regulate the science involved. Rebrikov’s plans could occur before the end of the year if he receives approval in time.