CRISPR-Cas9 can carry out precise genome editing even without the assistance of donor DNA templates, a team of scientists from Brigham and Women’s Hospital and the Broad Institute of MIT and Harvard have found.
A new scientific innovation is set to help scientists understand the causes of cancer with greater speed and precision than ever before. Rather than looking at individual gene mutations on their own, scientists can now create models incorporating a number of mutations.
For the first time, scientists have performed prenatal gene editing to prevent a lethal metabolic disorder in laboratory animals, offering the potential to treat human congenital diseases before birth.
Researchers at the Key Laboratory of Synthetic Biology in Shanghai have used CRISPR to create a new species of yeast that only has a single giant chromosome.
To find out which DNA repair enzymes are critical to homology-directed repair after CRISPR cutting, researchers have knocked out, one at a time, more than 2,000 genes known or suspected to be involved in DNA repair, a function critical to a healthy cell.
Scientists have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought.
The Nuffield Council on Bioethics has concluded that using gene editing tools on human embryos, sperm, or eggs for heritable gene editing could be ‘morally permissible’ in some cases.
Scientists are taking advantage of the “self-homing” abilities of cancer cells and are creating armies of cancer-killing cells using CRISPR gene-editing.
Researchers have for the first time, used gene-editing tools in adult monkeys to disable a gene throughout much of the liver.