With the cost of developing a drug doubling every 9 years, the pharma business model will soon become largely unsustainable. Yet we are in the middle of a data revolution. The availability and analysis of biodata to improve drug R&D represents the biggest opportunity for pharma to arrest the slide in productivity, cut costs, increase […]
Genomics has the potential to significantly improve the efficacy of drugs and develop targeted therapies.
“We Need to have Resilience and Tolerance for Failure” – Interview with Guillermo Del Angel, Alexion Pharmaceuticals
Dr. Guillermo del Angel is currently Sr. Director for Data Science, Genomics and Bioinformatics at Alexion Pharmaceuticals. He has been leading research efforts focused on applying and developing different machine learning, genetics and data science approaches to improve rare disease target discovery, drug development, and patient/disease characterization FLG: Could you give us an introduction of […]
A new drug created with artificial intelligence (AI) to treat patients with obsessive-compulsive disorder (OCD) will be entering human clinical trials this March – a first for AI. It has cut the drug development time from four and a half years to just 12 months, accelerating the time it typically takes to develop drugs for clinical trials.
A cancer-fighting compound has been found to also reduce fat in obese mice and could potentially help 93 million obese Americans fight their fat. Eric Prossnitz and his team at the University of New Mexico, USA discovered that the G-1 compound currently in clinical trials for breast cancer can also reduce fat and eliminate diabetes in mice.
AstraZeneca’s Olaparib has become the first gene-targeted medicine to show benefits in metastatic castration resistant prostate cancer.
Self-destructing mitochondria could be the initiation step for a range of neurogenerative diseases, new research shows. Mitochondrial dysfunction has been observed in the early stages of ALS, a neurogenerative disease that affects voluntary muscle movement. The symptoms of ALS are caused by the disintegration of the upper motor neurons of the brain, which is often […]
Pancreatic cancer cells can recruit immune cells to restore their oxygen supply in response to anti-angiogenesis therapies. To maintain their nutrient and oxygen supplies tumour cells initiate the formation of new blood vessels, in a process known as angiogenesis. Many cancer therapies work by blocking angiogenesis, as the process does not usually occur in […]
In a major shake-up of the pharmaceutical market, Biogen announced that it intends to seek approval from the FDA for its Alzheimer’s drug aducanumab. This follows their earlier announcement that the two clinical trials evaluating the effectiveness of the drug in patients had been discontinued. However, Biogen state that data from additional patients in the […]
Bacteria are constantly evolving resistance to antibiotics, and it is estimated that over 23,000 people have died from resistant infections in the US. The multiple methods that bacteria use to acquire antibiotic resistant genes are not well understood. However, for the first time a ‘harpoon’ mechanism that bacteria use to gain resistance has been caught […]
Returning for its 5th consecutive year, the 2020 Festival promises to be a unique experience, a crossroads for the entire genomics ecosystem to discover, meet, learn, have fun and celebrate. It is the largest genomics event in the UK and the fastest growing genomics event in the world. The Festival delivers incredible talks, speakers, cutting-edge content, inspirational topics, […]
Alzheimer’s is a degenerative disease characterized by the build-up of amyloid protein plaques in the brain. There are two conflicting theories for the cause of Alzheimer’s disease – the first being that the build up of the amyloid plaques directly causes the disease, and the second being that metabolic defects initiate the build-up of protein. […]
A new gene that enables people to survive on much less sleep has been identified. Most people require at least eight hours of sleep each night. Sleep deprivation can lead to multiple negative health impacts, including heart diseases and depression. However, some people have genetic variants which allow them to feel fully rested after only […]
The Digital DNA series explores the role of large-scale genetic testing in science, industry and society. We aim to understand both the benefits and risks of this emerging technology and see what the future may hold. In the finale of our Digital DNA series we talked to Dr Ian Roberts, the Chief Technology Officer of […]
A combination of Viagra and Plerixafor, both clinically approved drugs, could improve the efficacy of bone marrow stem cell transplants. Haemopoietic Stem cell transplants are life-saving treatments for a range of blood cancers, including lymphoma and leukaemia. The cells can differentiate into all types of blood cells to replace the abnormal cancer cells and restore […]
A new drug molecule that can block cell death could hold the potential for a range of regenerative treatments. Apoptosis is a form of controlled cell death that is essential for normal development and body function. The BLC-2 family of proteins control the process, with some protein molecules promoting cell survival and others promoting cell […]