Gene Therapy

Cancer Cells Can Cannibilise to Survive Chemotherapy

Cancer cells can consume neighbouring cells to survive chemotherapy, new research shows. Doxorubicin is a common chemotherapy drug that works by selectively damaging the DNA of cancer cells. However, multiple cancer cells have been observed to survive doxorubicin treatment to allow a relapse of the disease. These cancer cells can enter a form of dormancy, […]

Webinar: Advances in Improving HDR Efficiency for CRISPR Experiments

Front Line Genomics hosted the webinar Improved Methods for CRISPR Homology-Directed Repair Using Alt-R HDR Enhancer and ssDNA Donors with Optimized Design, which you can watch on demand for free here. The webinar described how to overcome some of the bottlenecks to using the CRISPR-Cas9 for genome manipulation and ensure its efficacy in a clinical […]

First CRISPR Law Prevents DIY Gene Therapy

The first law to regulate the use of genome editing technology has been passed in California.  Senator Ling Ling Chang authored the bill that requires sellers of gene therapy kits to include a label, and a notice prior to sale, stating that the CRISPR kits are not intended for self-administration. The bill is targeting ‘DIY […]

Sticky DNA Traps Cause Gallstone Formation

Sticky DNA traps produced by immune cells enable gallstones to stick together and grow, new research has revealed. Gallstones are stones that form in the gall bladder when the fats and minerals found in bile harden into a crystalline structure. Gallstones can cause inflammation and infections, depending on their size. Researchers investigated gallstones in patients […]

Damaged Neural Connections Repaired with Nanoparticles

A protein produced by specific cells in the brain has been shown to repair damaged brain networks. This discovery could allow a genetically engineered treatment for neurogenerative disorders such as Alzheimer’s. A key hallmark of neurogenerative diseases is the decay of the connections between neurons in the brain. If these connections could be restored it […]

Genes that Allow Fish to Re-grow Limbs also Present in Humans

The genes that enable a fish to re-grow limbs have been found to be present in humans, new research has found. This insight could help develop regenerative treatments in humans. Many species can regenerate limbs after amputation including fish, salamanders and geckos. This can be used as a mechanism to escape predators and heal from […]

BIO 2019 – An Interview with Irene Rombel, Senior Director and Head of Strategic Analysis at Janssen

With the recent conclusion of the Biotechnology Innovation Organization’s BIO 2019 event, we thought we’d talk to some of the fascinating individuals who were present to showcase their innovative ideas or technologies. Irene Rombel, Senior Director, Head of Strategic Analysis – External Innovation, Discovery, Product Development & Supply, at Janssen Research & Development, spoke at BIO 2019 about gene therapy and the next generation of biotherapeutics. We spoke to her about her thoughts on the gene therapy field, and the future for companies in that space.

New Clinical Trial Greatly Improves Genetic Rickets

A drug developed in part by Indiana University School of Medicine to alleviate the symptoms of X-linked hypophosphatemia (XLH), a disease which softens bones, has proven significantly more effective than conventional therapies.

Gene Therapy Could Heal Cells After Heart Attack

Gene therapy can make heart cells regenerate after a heart attack, King’s College London researchers have found. The study, published in Nature, stated that a small piece of genetic material called microRNA-199 delivered into a pig’s heart after myocardial infarction resulted in almost total cardiac recovery a month later.

New Cancer Pathway Opens Up New Treatment Possibilities

When the MDM2 gene acts with a specific protein found in cancer cells’ mitochondria, it can lead to cancer cell death. The study which discovered this fact, published by Mount Sinai researchers in Molecular Cell journal, could open new treatment opportunities for cancer patients in the future.