AstraZeneca and Cancer Research UK (CRUK) have announced that they will work together to open a new research centre in the UK, applying CRISPR and other functional genomics technologies to develop new cancer drugs. Specifically, the centre will study how genes and proteins interact with each other in cancer cells, and create disease models using genome-altering technologies based on this.
An innovative gene therapy treatment for Parkinson’s seems to relieve symptoms by rewriting the brain, scientists have found. Following the success of the therapy study, the researchers are planning a larger trial to start at the end of 2019.
Multinational biopharmaceutical company UCB has agreed to invest £1 billion in UK research and development (R&D), the government has announced in its latest Life Sciences Sector Deal. In the deal, £75 million will be invested into the development of new AI driven diagnostic tests while £50 million will be invested in digital pathology programmes and £37.5 million into regional digital innovation hubs.
Time to pop the champagne – 100,000 genomes have been reached. Well done Genomics England!
Baboons can live for up to 195 days with hearts taken from pigs and genetically engineered to avoid extreme immune reactions, three times longer than previous attempts, according to a report published in Nature journal.
A universal test which can detect traces of any cancer in a patient’s bloodstream in ten minutes has been developed by scientists from the University of Queensland. As it stands the test has a sensitivity of 90%, so is able to detect 90 in 100 cases of cancer.
The World Health Organization is establishing an expert panel to set guidelines and standards on the ethical and safety issues of gene editing, the body has announced. This follows the recent revelation that a scientist in China claimed he had edited the genes of twin babies to make them HIV resistant.
Certain genetic processes of neurodegeneration, as seen in dementia, have been identified by a research team led by UCLA scientists. Two major groups of genes which create over-productions of the tau protein, which is integral to loss of neurons seen in major dementia forms, were found using mouse models of dementia, although the researchers performed additional experiments which determined the same processes occur in human brains.
He Jiankui, the Chinese scientist who stunned the world by announcing the birth of two CRISPR-edited twins this week, has claimed that another woman is already pregnant with a separate CRISPR baby.
There is a large genetic component to attention deficit/hyperactivity disorder (ADHD), a study published recently in Nature Genetics has confirmed. The study assessed 20,183 individuals diagnosed with ADHD and 35,191 controls, finding variants in 12 independent loci which all contribute to ADHD.
Despite what was previously thought, some mitochondrial DNA can be inherited from fathers as well as mothers, scientists have found. A study, published recently in PNAS, began when the Cincinnati Children’s Hospital Medical Centre tested a child showing signs of fatigue and muscle pain to see if he had a mitochondrial disorder.