Reports

102 Genes Linked to Autism Spectrum Disorder

Researchers undertaking the largest genetic sequencing study of autism spectrum disorder (ASD) ever have identified 102 genes associated with the disorder, as opposed to the previous 65 in 2015, a move which they say will help greatly in differentiating ASD-related genes from those associated with intellectual disability and development delay.

Stem Cells and Gene Editing Create Mice From Two Mothers

Researchers at the Chinese Academy of Sciences have used two female mice to create offspring which subsequently went on to have healthy children of their own. While similar offspring were produced from two male mice, they did not survive for longer than a few days.

Blocking MDSC immune cells shown to slow TNBC metastasis

A new report from the University of Pennsylvania School of Veterinary Medicine has expanded what we know about the connection between myeloid-derived immunosuppressor cells (MDSCs) and aggressive disease. Their research has found that blocking the deltaNp63 protein on tumour cells which directs MDSCs to tumour and metastatic sites, or blocking the MDSCs themselves, reduces tumour growth and metastasis in a mouse model of triple-negative breast cancer (TNBC).

Immature human eggs created from blood cells

Japanese scientists have created an immature human egg using stem cells created from blood cells, as reported in the Science journal. Although such eggs have been created in a lab before, this is the first time human blood has been used to do it.

Human genome sequencing on PromethION: characterization of structural variants and repetitive regions

  At the VIB-UAntwerp Center for Molecular Neurology, we apply sequencing technologies to elucidate the genetic etiology of neurodegenerative brain diseases such as Alzheimer Disease and Frontotemporal Dementia. Structural variation and repetitive regions are insufficiently characterized using currently dominant short-read sequencing technologies. Long-read sequencing on the Oxford Nanopore PromethION has the potential for a comprehensive […]

Sequencing Buyers’ Guide

The development of the first automated DNA sequencers completely revolutionized the field of DNA sequencing and, eventually, made it possible to publish the first draft sequences of the human genome. Since then, a whole host of companies have developed their own approaches to DNA sequencing, resulting in a market that is filled with different possibilities […]