Genetics

Drug-Resistant Malaria Spreads Across Asia

A genomics study has revealed that a strain of malaria resistant to both drugs used for treatment has spread rapidly across Asia.  Malaria causes approximately a million deaths worldwide in each year and is a serious public health issue, particularly in Asia. The widely used anti-malarial drugs dihydroartemisinin and piperaquine have been relatively effective treatments […]

New Approaches to the Old Hunt for NASH Therapies – Webinar Summary

Front Line Genomics brought together thought leaders from around the world to discuss New Approaches to the Old Hunt for NASH Therapies, available to watch on-demand. The conversation was moderated by Donna Cryer, the President and CEO of the Global Liver Institute. The panel discussed why there has been limited progress in therapies for nonalcoholic […]

Genetic Study Identifies Diabetes Gene in African Populations

The largest scale genomic study in Africa has identified a new gene that is linked to the onset of diabetes in African populations. Interestingly, the gene has not been found to be linked to diabetes in European populations.   In type 2 diabetes the body is able to produce insulin but the body’s cells do […]

False Genetic Testing Results Condemned by Doctors

The inaccuracy of a genetic test that gave false positives to patients has resulted in doctors calling for a crackdown on genetic testing. If a woman’s BCRA gene is faulty,  her risk of breast and ovarian cancer is much higher than average. People with a family history of these cancers are often tested to identify […]

Digital DNA: Hacking DNA Databases – An Interview with Peter Ney

The Digital DNA series will explore the role of large-scale genetic testing in science, industry and society. We aim to understand both the benefits and risks of this emerging technology and see what the future may hold. In the first of our Digital DNA series, we talked to Dr. Peter Ney, a researcher in the […]

Gene Editing Induces Hallucinations in Mice

Scientists have genetically engineered neurons in mice to give them hallucinations. The research could help identify why certain people experience hallucinations, associated with several mental illnesses, and inform new treatments. Two genes were inserted into the neuron cells of the mice’s visual cortex, the part of the brain that processes visual information. One coded for […]

Gender Affects Gene Expression in Mammals

Although it has been known that different genes determine different characteristics in male and females, new research suggests that differences in gene expression has a much larger impact than previously thought. Many diseases and traits show difference between the sexes. For example, autism is more common in males than females, but multiple sclerosis is more […]

Anti-Starvation Mechanism Behind Obesity Epidemic

An evolutionary survival mechanism that helped early humans avoid starvation could be behind the obesity epidemic in society today. Starvation puts considerable stress on cells. The body responds with a mechanism that blocks fat from burning when the body is starving, injured or cold. This enables energy to be conserved so people can survive longer, […]

Biobank 2019 — An Interview with Professor Joshua Denny, Vanderbilt University Medical Center

The UK Biobank’s 2019 scientific conference concluded this month, showcasing fantastic speakers on topics ranging from use of the UK Biobank, to using genomics to understand individual risk. Among them was Professor Josh Denny, Vanderbilt University. FLG spoke to him about his talk on phenome-wide association studies (PheWAS): a research technique used to understand what disease associations can be made with a given gene.

RNA Key to Anti-Ageing Skincare

Scientists have found that RNA production is behind the regenerative affects of laser skincare treatments. Laser treatments are a widespread cosmetic procedure to make skin appear younger and healthier. The laser slightly damages the skin cells, forcing them to repair themselves. After the repair process, the skin looks younger, but until recently the mechanism to […]

Study Suggests Genetic Basis for Anorexia

A new genetic study has revealed anorexia, previously thought to be solely a psychiatric disease, is influenced by metabolic factors. Anorexia is an eating disorder and a serious mental health condition. Sufferers try to keep their weight as low as possible by eating as little as possible or exercising as much as they can. Sufferers […]

Genomic Barcode Identifies Immune Cells that Can Tackle Cancer

Researchers have developed a new technique to pinpoint immune cells in cancer patients that are reactive against their disease. This research could lead to more targeted immune-based therapies for cancer patients. Immunotherapy is a relatively new field of cancer treatment which works by promoting the patient’s immune system to fight against the cancer. Although immune […]

Healthy Lifestyle can Reduce Genetic Risk for Dementia

A study has shown that you can reduce your risk of getting dementia by adapting a healthy lifestyle, regardless of your genetic pre-disposition. Genetic factors can increase a person’s likelihood of getting dementia, but until now it was not known if making lifestyle changes could reduce this risk. 196,383 individuals above 60 years of age […]

Malnourished Children Recover Better with Microbiome Repairing Food

A new treatment for malnourished children, using food that promotes a healthy microbiome, has been found to aid recovery better than current alternatives. Malnourished children often struggle to recover and find gaining weight again extremely difficult, even with sufficient food. Scientists have long suspected this is due to the role of the gut microbiome. Gut […]