The CCR5 gene has been researched by scientists since the 1990s, and has a number of roles which have not yet properly been uncovered. Loss of the gene’s function is known, however, to increase the risk of potentially fatal reactions to some diseases, and has shown an ability to enhance learning in mice.
Altering the genome, typically to better understand gene and protein function. This also paves the way for gene therapy.
Baboons can live for up to 195 days with hearts taken from pigs and genetically engineered to avoid extreme immune reactions, three times longer than previous attempts, according to a report published in Nature journal.
The World Health Organization is establishing an expert panel to set guidelines and standards on the ethical and safety issues of gene editing, the body has announced. This follows the recent revelation that a scientist in China claimed he had edited the genes of twin babies to make them HIV resistant.
He Jiankui, the Chinese scientist who stunned the world by announcing the birth of two CRISPR-edited twins this week, has claimed that another woman is already pregnant with a separate CRISPR baby.
Twin girls in China have allegedly been born after having their embryonic genetic code modified using CRISPR. Chinese researcher He Jiankui, from the Southern University of Science and Technology, claims to have turned off a gene called CCR5 to offer total protection against HIV, as well as smallpox and cholera.
Researchers at the Chinese Academy of Sciences have used two female mice to create offspring which subsequently went on to have healthy children of their own. While similar offspring were produced from two male mice, they did not survive for longer than a few days.
For the first time, scientists have performed prenatal gene editing to prevent a lethal metabolic disorder in laboratory animals, offering the potential to treat human congenital diseases before birth.
Researchers at the Key Laboratory of Synthetic Biology in Shanghai have used CRISPR to create a new species of yeast that only has a single giant chromosome.
To find out which DNA repair enzymes are critical to homology-directed repair after CRISPR cutting, researchers have knocked out, one at a time, more than 2,000 genes known or suspected to be involved in DNA repair, a function critical to a healthy cell.
The NIH has committed up to $45.5M to support its Somatic Cell Genome Editing programme. The money will make up a series of grants to be paid over the next four fiscal years.
Americans are more likely to anticipate negative than positive effects from widespread use of gene-editing technology.
Prenatal gene therapy has been used to prevent acute neuronopathic Gaucher’s disease, however this approach is using viruses to deliver normal copies of genes.