The first gene editing clinical trial sponsored by US companies has released data to STAT news showing promising results using a CRISPR based therapy. Sickle cell anaemia and beta thalassemia patients required no further treatments after one appointment.
Altering the genome, typically to better understand gene and protein function. This also paves the way for gene therapy.
One year on from the birth of world’s first CRISPR-edited babies in China, Jennifer Doudna, writes in Science what this and the ensuing controversy has meant for the field and society’s perception of the technology, as well as to outline what should be done next.
In an exciting new development, researchers have now developed a CRISPR-Cas9 system complexed with Chemical Epigenetic Modifiers (CEMs) that allowed dose-dependent activation of gene expression.
A new version of the CRISPR-Cas9 protein has been developed that can increase the targeting efficiency of the gene editing process. Currently the CRISPR Cas-9 system is the most widely used gene editing technique. However, concerns about CRISPR editing genes other than the ones it is targeted to have hindered its introduction into gene-therapy treatments […]
Press Release from National Institute of Health The National Institutes of Health plans to invest at least $100 million over the next four years toward an audacious goal: develop affordable, gene-based cures for sickle cell disease (SCD) and HIV. The Bill & Melinda Gates Foundation will also invest $100 million toward this goal. The […]
A new gene editing tool known as Prime Editing has been developed that could reverse the harmful mutations in over 89% of genetic diseases. Building on the CRISPR Success Currently the CRISPR Cas-9 system is the most widely used gene editing technique. However, concerns about CRISPR editing genes, other than the ones it is targeted […]
CRISPR gives us the ability to precisely edit genes within cells, and the technique holds enormous potential for transforming the gene therapy space. However, concerns about CRISPR editing genes other than the ones it is targeted to have hindered its introduction into patient treatments. Known as off-target mutations, these unintended gene edits caused by CRISPR […]
Manassas, VA – October 1, 2019 – ATCC launched its new ATCC Genome Portal, a publicly available database of reference-quality genome sequences matched to authenticated ATCC biological materials that will help researchers interpret and reproduce their results with confidence. The portal, which launched with an initial 250 genome sequences of widely used bacterial strains, delivers […]
Our guest contributor Dr Neil Lamb continues his fortnighty Shareable Science Blog with an extract from the annual guidebook ‘A Year in Genetics as Told by Tomorrow’s Textbooks‘. Neil is the Vice President for Educational Outreach at the HudsonAlpha Institute for Biotechnology and Shareable Science will explore how genetics is relevant to people in their […]
Molecular Assemblies recently announced a $12.2M series A financing to advance their enzymatic DNA synthesis technology. We talked to Michael Kamdar, the CEO and president of Molecular Assemblies, to discuss how enzymatic DNA synthesis could revolutionise biotechnology. FLG: Can you introduce Molecular Assemblies? MK: Molecular Assemblies is a synthetic biology company founded in 2013, and […]
Normally harmless fruit flies have been gene edited using CRISPR, with genes from the monarch butterfly, to make them poisonous to both their predators and humans. The monarch caterpillars feed on the toxic plant milkweed. When the caterpillars metamorphosise into butterfly’s they retain the milkweed toxins in their tissues, which make them poisonous to potential […]
Ultrasound has been used successfully to view gene expression in mammalian cells, in a development that could transform cellular imaging technologies. Methods of visualising gene expression in cells are essential to enable continued advances in genomic medicine. Fluorescent techniques are currently the most widely used cellular imaging technique, despite their limitations. Fluorescent ‘tags’ can be […]
The gene editing technique CRISPR has been used successfully on reptiles for the first time, to produce four albino lizards. Although birds, mammals and fish have been successfully edited with CRISPR, reptiles have proved more challenging targets for the CRISPR/Cas-9 system due to the differences in their reproductive physiology. The brown anole lizard, Anolis sagrei, […]
A 28 year-long genomics study revealed how crops will respond to the rising temperatures associated with climate change. Over the study, period the temperature in Israel, where the study was conducted, increased by 2°C, even higher than the 1.5°C global temperature increase limit agreed in the Paris Climate Change Agreement. Food scarcity will be one […]
Front Line Genomics hosted the webinar Improved Methods for CRISPR Homology-Directed Repair Using Alt-R HDR Enhancer and ssDNA Donors with Optimized Design, which you can watch on demand for free here. The webinar described how to overcome some of the bottlenecks to using the CRISPR-Cas9 for genome manipulation and ensure its efficacy in a clinical […]