For the first time, CRISPR-Cas9 has been combined with electronic graphene transistors to create a new handheld device which can detect specific mutations in the genome within minutes. The device can be used to quickly diagnose genetic disorders and diseases or determine the accuracy of gene-editing techniques.
Altering the genome, typically to better understand gene and protein function. This also paves the way for gene therapy.
The scientists of seven nations have called for a halt to gene-editing experiments seeking to alter heritable traits in human babies.
New information from China has suggested that the twins recently created using CRISPR gene-editing technology to make them HIV-resistance could also develop genetically-enhanced brains.
Researchers from the Wake Forest Institute for Regenerative Medicine (WFIRM) have determined a new way to deliver DNA editing tools so that the presence of their proteins in cells is reduced, in what they have called a “hit and run” approach.
Genomics England, NHS England and The Royal Society are holding a scientific meeting at the Royal Society in Carlton House Terrace to celebrate the successful conclusion of the 100,000 Genomes Project, which was declared finished in December last year.
For the first time, scientists have changed human stem cells into functional insulin-producing cells in mice, potentially promising a breakthrough in treatment for those suffering from type 1 diabetes.
Scientists at the Institute of Neuroscience (ION) in China have reportedly used gene-editing technology to disable a certain gene vital to sleep-cycle in macaque monkeys. This prototype could create populations of genetically identical monkeys to allow scientists to better study the mechanisms of complex human disorders.
The introduction of multi-omic research, the advancement of AI and machine learning to improve nearly every aspect of sequencing and data analysis, are just some of the big changes that will only become more prevalent in the future. We spoke to Angela Douglas MBE, Scientific Director of Genetics Laboratories at Liverpool Women’s Hospital, for her opinions on the changing nature of genomics and the trends to watch out for.
A new study published in Cell magazine and co-authored by CRISPR pioneer Jennifer Doudna has suggested a potential solution to the unwanted side-effects of using CRISPR in the body. The study details using a “switch” mechanism which could keep the Cas9 enzyme turned off until it reaches its target site.
A modified version of CRISPR has been used to reverse genetic obesity in two different mouse models without editing any genes. The technique uses the guidance system in CRISPR to target certain genetic sequences and amplifies existing gene activity to ramp up protein production.
The CCR5 gene has been researched by scientists since the 1990s, and has a number of roles which have not yet properly been uncovered. Loss of the gene’s function is known, however, to increase the risk of potentially fatal reactions to some diseases, and has shown an ability to enhance learning in mice.
Baboons can live for up to 195 days with hearts taken from pigs and genetically engineered to avoid extreme immune reactions, three times longer than previous attempts, according to a report published in Nature journal.
The World Health Organization is establishing an expert panel to set guidelines and standards on the ethical and safety issues of gene editing, the body has announced. This follows the recent revelation that a scientist in China claimed he had edited the genes of twin babies to make them HIV resistant.