Healthcare

Genomics will change what patients expect from their provider, as well as change how physicians treat them. Before this happens, education on both sides is needed. This month we look at some of the big talking points.

Interview – Cath Stanley, CEO of the Huntington’s Disease Association

We talked to Cath Stanley, the CEO of the Huntington’s Disease Association. The charity offers support to those affected by Huntington’s, as well as carers and healthcare professionals, to ensure patients get the best care available. FLG: What is Huntington’s disease and What Are the Symptoms? CS: Huntington’s disease is a rare genetic disorder. It […]

First Artificial Human Liver Created

Researchers have created the first artificial human liver model from genetically engineered human liver cells. It is hoped that the artificial liver will be an effective model to study fatty liver diseases. Non-alcoholic fatty liver disease (NAFLD) is a condition where fat builds up in the liver, eventually leading to liver failure. There is currently […]

Multi-Drug Resistant Bacteria Found Throughout London

Bacteria resistant to multiple antibiotic drugs have been found throughout London, including on the underground and in hospitals, new research shows. Antibiotic resistant bacteria are a serious public health issue, which make the treatment of many infections difficult. Bacteria can acquire resistance either through the selection pressure of antibiotics, or from genetic transfer between cells. […]

CRISPR Activation Technique Improves Muscular Dystrophy Symptoms in Mice

A CRISPR activation technique has been shown to improve the symptoms of muscular dystrophy disease in mice. Muscular dystrophy is a hereditary condition characterised by progressive weakening and wasting of the muscles. A specific type of muscular dystrophy is caused by mutations in the gene Lama2, which codes for the protein laminin. Mutations in the […]

WHO Releases Statement Condemning Further Germline Genome Editing

The World Health Organisation (WHO) has released a statement calling for a stop to germline editing in humans. This is in light of recent controversial experiments in the field which emphasized patient safety concerns. Germline editing refers to the genome editing of reproductive cells. These changes are inheritable, and the technology has the potential to […]

Cigarette Smoke Makes MRSA Superbug More Resistant to Antibiotics

Cigarette smoke has been found to make MRSA bacteria more resistant to antibiotics. The MRSA bacteria, s. aureus, can cause severe infections in humans. These are difficult to treat as MRSA is resistant to most commonly used antibiotics. MRSA poses a major problem in hospitals due to the high numbers of patients with open wounds […]

Chris Wigley Appointed CEO of Genomics England

Genomics England has today announced the appointment of Chris Wigley as Chief Executive Officer, with effect from 1 October. Chris joins Genomics England from QuantumBlack, a world leader in machine learning and artificial intelligence. Machine learning is critical in the analysis of the vast amounts of data involved in genomics, so Chris’ expertise in this […]

Gene Discovery Explains Failure of Alzheimer’s Drugs

A gene discovery has explained why current Alzheimer’s drugs don’t work for lots of patients, and why so many new drugs fail in clinical trials. The acetylcholine receptor α7nAChR has long been a target of interest for Alzheimer’s drugs. The neurotransmitter acetylcholine is involved in memory and learning processes. Despite acetylcholine being linked to the […]

Genetic Similarities of Rare Bone Cancer Between Children and Dogs

A rare and difficult to cure bone cancer in children has been found to have significant genetic similarities with the same type of cancer in dogs. This insight could improve understanding of the disease and lead the development of more effective treatments. Osteosarcoma (OS) is a rare bone cancer in children, but relatively common in […]

UK Government Announces Genomics Policies

As it is announced that Boris Johnson will be the next UK Prime Minister, the UK government has released their genomic policies for the 2020s. The policies aim to ‘build on [the Uk’s] position as a world leader in genomics.’ From 2023-2034 the NHS aims to analyse five million genomes and fully sequence one million […]

Drug-Resistant Malaria Spreads Across Asia

A genomics study has revealed that a strain of malaria resistant to both drugs used for treatment has spread rapidly across Asia.  Malaria causes approximately a million deaths worldwide in each year and is a serious public health issue, particularly in Asia. The widely used anti-malarial drugs dihydroartemisinin and piperaquine have been relatively effective treatments […]

New Approaches to the Old Hunt for NASH Therapies – Webinar Summary

Front Line Genomics brought together thought leaders from around the world to discuss New Approaches to the Old Hunt for NASH Therapies, available to watch on-demand. The conversation was moderated by Donna Cryer, the President and CEO of the Global Liver Institute. The panel discussed why there has been limited progress in therapies for nonalcoholic […]

Genetic Study Identifies Diabetes Gene in African Populations

The largest scale genomic study in Africa has identified a new gene that is linked to the onset of diabetes in African populations. Interestingly, the gene has not been found to be linked to diabetes in European populations.   In type 2 diabetes the body is able to produce insulin but the body’s cells do […]

False Genetic Testing Results Condemned by Doctors

The inaccuracy of a genetic test that gave false positives to patients has resulted in doctors calling for a crackdown on genetic testing. If a woman’s BCRA gene is faulty,  her risk of breast and ovarian cancer is much higher than average. People with a family history of these cancers are often tested to identify […]