Molecular Biology

Suicidal Mitochondria Could be the Cause of Multiple Neurogenerative Diseases

Self-destructing mitochondria could be the initiation step for a range of neurogenerative diseases, new research shows. Mitochondrial dysfunction has been observed in the early stages of ALS, a neurogenerative disease that affects voluntary muscle movement. The symptoms of ALS are caused by the disintegration of the upper motor neurons of the brain, which is often […]

Vitamin D Makes Melanoma Cells Less Aggressive

Vitamin D has been shown to make melanoma cells less aggressive by interfering in a key signaling pathway that promotes cancer cell growth. Melanoma is a form of skin cancer which can be initiated by genetic damage from sun exposure. Melanoma patients are therefore encouraged to reduce their sun exposure to mitigate any further damage. […]

Artificial Enzymes Improve Immunotherapy Treatments

Artificial nanoenzymes have shown promise in improving both the selectivity and efficacy of immunotherapy treatment. Only a small proportion of patients see the benefits of immunotherapy as tumour cells can employ a multitude of disguises to avoid detection by the immune system. Too ensure more patients can experience the benefits of immunotherapy, new technologies are […]

Bacteria ‘Harpoon’ DNA to Gain Antibiotic Resistance

Bacteria are constantly evolving resistance to antibiotics, and it is estimated that over 23,000 people have died from resistant infections in the US. The multiple methods that bacteria use to acquire antibiotic resistant genes are not well understood. However, for the first time a ‘harpoon’ mechanism that bacteria use to gain resistance has been caught […]

Alzheimer’s Could have Metabolic Cause

Alzheimer’s is a degenerative disease characterized by the build-up of amyloid protein plaques in the brain. There are two conflicting theories for the cause of Alzheimer’s disease – the first being that the build up of the amyloid plaques directly causes the disease, and the second being that metabolic defects initiate the build-up of protein. […]

Cell Death Blocker Could Aid Regenerative Medicine

A new drug molecule that can block cell death could hold the potential for a range of regenerative treatments. Apoptosis is a form of controlled cell death that is essential for normal development and body function. The BLC-2 family of proteins control the process, with some protein molecules promoting cell survival and others promoting cell […]

Shareable Science: Hachimoji – A New Genetic Language?

Our guest contributor Dr Neil Lamb continues his fortnighty Shareable Science Blog with an extract from the annual guidebook ‘A Year in Genetics as Told by Tomorrow’s Textbooks‘. Neil is the Vice President for Educational Outreach at the HudsonAlpha Institute for Biotechnology and Shareable Science will explore how genetics is relevant to people in their […]

How our Cells Sense Oxygen Wins Nobel Prize

The 2019 Nobel Prize for Physiology and Medicine has been awarded to three scientists who discovered how cells sense and adapt to oxygen levels. Sir Peter Ratcliffe, of the University of Oxford and Francis Crick Institute, William Kaelin, of Harvard, and Gregg Semenza, of Johns Hopkins University share the Nobel. Oxygen Sensing in Cells Oxygen […]

Synthetic DNA: An Interview with Michael Kamdar, CEO Molecular Assemblies

Molecular Assemblies recently announced a $12.2M series A financing to advance their enzymatic DNA synthesis technology. We talked to Michael Kamdar, the CEO and president of Molecular Assemblies, to discuss how enzymatic DNA synthesis could revolutionise biotechnology. FLG: Can you introduce Molecular Assemblies? MK: Molecular Assemblies is a synthetic biology company founded in 2013, and […]

Ultrasound Used to View Gene Expression

Ultrasound has been used successfully to view gene expression in mammalian cells, in a development that could transform cellular imaging technologies. Methods of visualising gene expression in cells are essential to enable continued advances in genomic medicine. Fluorescent techniques are currently the most widely used cellular imaging technique, despite their limitations. Fluorescent ‘tags’ can be […]

Anxiety Can Disrupt Mitochondrial Function

Anxiety is a serious mental disorder characterized by panic attacks and a strong emotional response to stress. It can be initiated by stressful life events, such as bereavement, divorce and conflict. It is known that some people are more susceptible to anxiety than others, as not all who experience stressful life events necessarily experience anxiety. […]

Senescent Cells may Cause Thrombosis

Cell senescence may explain why people suddenly become more prone to deep vein thrombosis once they reach the age of 45, new research has shown. Thrombosis is the formation of a blood clot inside of a blood vessel, which disrupts the flow of blood around the body. Thrombosis incidence is extremely low in people below […]

Webinar: Advances in Improving HDR Efficiency for CRISPR Experiments

Front Line Genomics hosted the webinar Improved Methods for CRISPR Homology-Directed Repair Using Alt-R HDR Enhancer and ssDNA Donors with Optimized Design, which you can watch on demand for free here. The webinar described how to overcome some of the bottlenecks to using the CRISPR-Cas9 for genome manipulation and ensure its efficacy in a clinical […]