Patients

Leukaemia Cells are Addicted to Vitamin B6

Researchers from the Cold Spring Harbor Laboratory (CSHL) and Memorial Sloan Kettering Cancer Center (MSK) have discovered that Acute Myeloid Leukaemia (AML) grows by taking advantage of the B6 vitamin to accelerate cell division. The findings could pave the way for a treatment that can stop cancer growth by manipulating the enzyme that pushes B6 to make proteins essential for cell division.

Interview with Dr Rona Strawbridge, UKRI Innovation

Dr Rona Strawbridge has been using genetics to try to understand complex diseases, who’s work has focused much on obesity, type 2 diabetes and cardiovascular disease, and more recently serious mental illness. We managed to have a chat with Rona ahead of her speaking at the Festival of Genomics about her work and why she’s excited to be speaking at the festival this year.

Knocking Out HIV in Newborns with a Single Dose of Antibodies

New research on nonhuman primates has found that a single dose of antibody-based treatment can prevent HIV transmission from mother to baby. Published in Nature Communications, this research is the first to find that a single dose of broadly neutralising antibodies given after viral exposure can prevent SHIV infection in nonhuman primate new-borns.

Researchers Discover How to Silence Pain Through Epigenetics

Scientists at Navega Therapeutics in San Diego, California have discovered a way to target DNA to stop pain signals being sent and eliminate pain. In an article published by Pharmafile, the treatment could be available in five years to help sufferers of chronic pain or with long-term pain problems.

A New Way to Predict the Progression of Alzheimer’s Disease

Researchers have investigated the use of PET imaging to see whether beta-amyloid and tau can predict subsequent brain atrophy in Alzheimer’s disease. Published in Science Translational Medicine, the findings showed that tau tangles could be used to predict how much shrinkage will occur and where, which was particularly strong in younger patients.

He Jiankui Sentenced to Three Years in Prison & a Third CRISPR Baby Confirmed

Earlier this week, He Jiankui, the scientist behind the world’s first gene-edited twin babies, was sentenced to three years in prison and fined three million yuan (£327,000) for “illegal medical practice”. In late 2018, He Jiankui along with his team carried out CRISPR gene editing on twin girls, dubbed Lulu and Nana, to provide immunity against HIV.

Liver Fat Leaks Linked to Type 2 Diabetes

Researchers at Newcastle University, UK have been the first to confirm that fat over-spills from the liver into the pancreas can trigger Type 2 diabetes. Published in Cell Metabolism, the researchers observed the link between excess fat within both the liver and pancreas and the development of Type 2 diabetes, and how this condition can be reversed.

Detecting Leukaemia with Artificial Intelligence

Researchers at the German Centre for Neurodegenerative Diseases (DZNE) and the University of Bonn have investigated the use of artificial intelligence to detect one of the most common forms of blood cancer – acute myeloid leukaemia (AML) – with high reliability. Published in iScience, the technique was used to analyse the expression of certain genes in cells of the blood.

Predicting Breast Cancer Recurrence After 10-Years with MRI Scans

Researchers at Penn Medicine have developed an imaging technique that can provide a non-invasive characterisation of tumour heterogeneity. They used Magnetic Resonance Imaging (MRI) and radiomics – an emerging field of medicine that uses algorithms to extract large amounts of features from medical images

The New Genetic Risk Score for Ischaemic Stroke

Scientists have developed a new genetic risk score that is similarly or more predictive than commonly known risk factors for stroke. They developed this meta-scoring approach model to identify individuals at a 3-fold increased risk of developing ischaemic stroke – one of the leading causes of disability and death world-wide

Asthma Could be Linked to Your Airway Microbiome

Microbes are well known to form entire communities in our guts – or microbiomes, but less is known about the communities we have in our lungs. Researchers from Washington University School of Medicine in St. Louis investigated the correlation between microbial colonisation in the upper airway and the severity of asthma symptoms