Patients

“We Need to have Resilience and Tolerance for Failure” – Interview with Guillermo Del Angel, Alexion Pharmaceuticals

Dr. Guillermo del Angel is currently Sr. Director for Data Science, Genomics and Bioinformatics at Alexion Pharmaceuticals. He has been leading research efforts focused on applying and developing different machine learning, genetics and data science approaches to improve rare disease target discovery, drug development, and patient/disease characterization FLG: Could you give us an introduction of […]

Coronavirus Genome Now On UCSC Genome Browser

The biomolecular code of the deadly Wuhan pneumonia virus, the coronavirus, is now available to view on the UCSC Genome Browser. With nearly 41,000 cases and 910 deaths to date, the deadly virus has forced more than 50 million people to be quarantined by the Chinese government in an aim to stop the spread of the virus.

OCD Drug Designed by Artificial Intelligence Set to Enter Clinical Trials

A new drug created with artificial intelligence (AI) to treat patients with obsessive-compulsive disorder (OCD) will be entering human clinical trials this March – a first for AI. It has cut the drug development time from four and a half years to just 12 months, accelerating the time it typically takes to develop drugs for clinical trials.

East Asian and European Genomic Differences Found in Lung Cancer

New research from institutions in Singapore and China has identified genetic differences that occur between lung adenocarcinomas in East Asians and Europeans. Published in Nature Genetics, the researchers found that lung adenocarcinomas had more stable genomes in East Asians than in Europeans, and a stronger difference in smokers compared to non-smokers.

Interview with Dr Halima Moncrieffe, Assistant Professor, Cincinnati Children’s Hospital Medical Center

Dr Halima Moncrieffe is an Assistant Professor at Cincinnati Children’s Hospital, ranked top 3 in the USA, where she combines genomics with immunology to understand medication response and disease etiology. Halima is an award-winning immunologist who’s ultimate goal is to move towards a cure for Juvenile Idiopathic Arthritis, so children can live pain-free and to their full potential

102 Genes Linked to Autism Found in Largest-Ever Study

The largest study on autism spectrum disorders (ASD) to date has identified 102 genes involved in the disorder, including 37 new genes that had not been recognised before. Published in Cell, the findings help researchers better understand the causes of the disorder, and could possible help in developing new drug therapies for children with severe impairments.

New Polymer & Protein Design Can Regrow Damaged Nerves

A cross-section image of the nerve conduit embedded in microspheres. Credit: N.B. Fadia et al., Science Translational Medicine (2019) Researchers at the University of Pittsburgh School of Medicine have created a polymer nerve guide made out of biodegradable material filled with growth-promoting proteins that can regenerate long sections of damaged nerves. Published in Science Translational […]

New Genetic Test Predicts Glaucoma-Related Blindness

Researchers at QIMR Berghofer Medical Research Institute and Flinders University, Australia have identified 107 genes associated with increased risk of developing glaucoma. The researchers also developed a genetic test to screen those who are at risk of developing the condition, in the hopes of intervening before symptoms of the disease, such as vision loss, occur.

Monitoring Breast Cancer with Magnetised Molecules

A new type of scan has been used to visualise regions of breast tumours that are active with magnetising molecules in research funded by Cancer Research UK. The work used carbon-13 hyperpolarised imaging to monitor breast cancer, allowing not only visualising the tumour as a whole, but details of its internal metabolic state as well.

Leukaemia Cells are Addicted to Vitamin B6

Researchers from the Cold Spring Harbor Laboratory (CSHL) and Memorial Sloan Kettering Cancer Center (MSK) have discovered that Acute Myeloid Leukaemia (AML) grows by taking advantage of the B6 vitamin to accelerate cell division. The findings could pave the way for a treatment that can stop cancer growth by manipulating the enzyme that pushes B6 to make proteins essential for cell division.