FLG: Could you give us an introduction of yourself and the work you do? I’m Luigi Grassi and I’m an Informatics Scientist at AstraZeneca. I’m responsible for designing and performing bioinformatical analyses of the high throughput sequencing experiments we use to characterise stable cell lines expressing biotherapeutics. FLG: What motivated you to pursue a career […]
“We are all Billionaires in Terms of our Genome Data” – Interview with Prof. Ernst Hafen, Professor of Systems Genetics, ETH Zurich
Professor Ernst Hafen is based at the Institute of Molecular Systems Biology at ETH Zurich. He studied the developmental and cell biology of fruit flies for over 30 years and now focuses on human genomic data and what it can do for health research. FLG: Could you give us an introduction of yourself and the […]
“We Are Starting to Appreciate Non-Coding DNA” – Interview with Dr Sandra Smieszek, Vanda Pharmaceuticals Inc.
Dr. Sandra Smieszek is the Head of Genetics at Vanda Pharmaceuticals Inc. She trained at the Institute for Computational Biology and has extensive experience in several aspects of human genetic studies including case control studies from clinical sequencing, whole genome explorative analyses, reverse phenotyping enabling precision medicine and pharmacogenomics.
The biomolecular code of the deadly Wuhan pneumonia virus, the coronavirus, is now available to view on the UCSC Genome Browser. With nearly 41,000 cases and 910 deaths to date, the deadly virus has forced more than 50 million people to be quarantined by the Chinese government in an aim to stop the spread of the virus.
A new drug created with artificial intelligence (AI) to treat patients with obsessive-compulsive disorder (OCD) will be entering human clinical trials this March – a first for AI. It has cut the drug development time from four and a half years to just 12 months, accelerating the time it typically takes to develop drugs for clinical trials.
New research has identified mutations that could lead to the lengthening of telomeres, a hallmark of cancer cells and an important focus in developing targeted treatments. Scientists from the German Cancer Research Center looked at cancer cells to find the ways some of them achieve immortality in a study as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG).
A cancer-fighting compound has been found to also reduce fat in obese mice and could potentially help 93 million obese Americans fight their fat. Eric Prossnitz and his team at the University of New Mexico, USA discovered that the G-1 compound currently in clinical trials for breast cancer can also reduce fat and eliminate diabetes in mice.
Scientists show how hMPV virus exploits RNA modification to prevent host differentiation of self and non-self RNA, thereby evading an innate immune response. This mechanism could serve as a hMPV vaccine target, and potentially more if found to be well-conserved.
New research from institutions in Singapore and China has identified genetic differences that occur between lung adenocarcinomas in East Asians and Europeans. Published in Nature Genetics, the researchers found that lung adenocarcinomas had more stable genomes in East Asians than in Europeans, and a stronger difference in smokers compared to non-smokers.
Gene variants that could play a role in the incongruence transgender individuals experience may have been found in the genes for oestrogen receptor pathways. Published in Nature, this study identified some of the first biological evidence that linked 21 gene variants in 19 genes with a possible role in sex-specific development during birth in an […]
The study of four children – two of whom were buried approximately 8,000 years ago and two 3,000 years ago – from Shum Laka, Cameroon has revealed new insights into how Africa was populated.
Interview with Dr Halima Moncrieffe, Assistant Professor, Cincinnati Children’s Hospital Medical Center
Dr Halima Moncrieffe is an Assistant Professor at Cincinnati Children’s Hospital, ranked top 3 in the USA, where she combines genomics with immunology to understand medication response and disease etiology. Halima is an award-winning immunologist who’s ultimate goal is to move towards a cure for Juvenile Idiopathic Arthritis, so children can live pain-free and to their full potential
Dr Michelle Krishnan is the Translational Medicine Leading in Rare Diseases at Roche where she focuses on developing transformative therapies for rare neurodevelopmental disorders to deliver meaningful benefit for patients and families, and is responsible for the clinical development of programmes from early research to clinical trials.
Karen Lighting Jones, Head of Future Place at Roche. Back in 2016, Dame Sally Davies concluded her Chief Medical Officer annual report by saying “Genomics is not tomorrow, it’s here today. I believe genomic services should be available to more patients, whilst being a cost-effective service in the NHS”.
Interview with Dr Cecilia Domínquez Conde, Postdoctoral Fellow, Teichmann Lab, Wellcome Sanger Institute
Dr Cecilia Dominguez Conde is a postdoctoral fellow at the Teichmann Lab, Wellcome Sanger Institute. During her PhD, she discovered DOCK2 and POLD immunodeficiencies, and her current work focuses on studying the human immune system across different body sites and unravelling the clonal distributions of T and B lymphocytes. Cecilia is speaking at this years Festival of Genomics, and we found out what she’s looking forward to the most.