Research

nQ Medical Wins “Most Innovative Breakthrough” Prize at D4 Conference

Out of a whole host of engaging and enjoyable moments at Front Line Genomics’ recent Data Driven Drug Development (D4) conference, held in Boston on 20-21 March, one of the most memorable was definitely the triumph of nQ Medical in our innovation showcase, beating out three other contenders for the claim to be “most innovative” of the technologies on display.

More Than 13,000 Genetic Edits Made to Single Cell

Harvard College researchers have announced that more than 13,000 genetic alterations have been made to a single cell using CRISPR technology. This work is designed to edit genomes at a much larger scale than currently possible.

Biogen’s Lead Alzheimer’s Drug Falls Down at Phase Three Trials

Pharma giant Biogen and its Japanese partner Eisai have made the decision to halt two phase 3 trials of aducanumab, a drug created to slow Alzheimer’s by targeting brain-destroying beta-amyloid fragments. An independent monitoring committee decided that the drug was unlikely to benefit patients compared with a placebo.

Gene Insertion Allows Blind Mice to See Again

Scientists from the University of California have announced a possible alternative option to electronic eye implants for those who have lost their sight: gene therapy. Virus-delivered genes for green opsin gave blind mice sight enough to determine patterns on an iPad, they found, with the therapy possibly ready for clinical trials in three years’ time.

Researchers Identify PTSD Blood Biomarkers

Indiana University School of Medicine researchers have found blood-based genetic markets of psychological stress which could lead to better diagnostics for post-traumatic stress disorder (PTSD), and bring forward new drug development leads.

CAR-T Therapy Destroys Lupus in Mice

A number of mice have been cured entirely of lupus by a CAR-T treatment which wipes out the immune system’s B cells by spotting the CD19 protein marker which nearly all B cells carry.

Second Set of “Semi-Identical Twins” Identified

Twins born in Australia have become the second-ever-identified pair of “semi-identical” twins, and the first to be detected before they were born. Such cases come about when twins receive 100% identical genes from their mother, but not from their father.

First Common Risk Genes for Autism Discovered

Researchers from the Broad Institute in the US and Danish iPSYCH project have discovered the first common genetic risk variants for autism and uncovered genetic differences in clinical subgroups of autism.