A gene that codes for a telomere protein is the key to regulating stem cell pluripotency, new research shows. Pluripotent stem cells have the ability to differentiate into any type of specialised cell in the body. They hold huge potential for a range of regenerative medical treatments. Scientists have previously struggled to understand the genetic […]
The transcriptome gives a fuller picture of how genes are expressed. RNA sequencing allows for more detailed information on cellular pathways and expression levels in cancer studies.
A new technique to analyse the tumour DNA present in patient’s blood circulations is an effective method to monitor breast cancer progression. The technique has been shown to give a hundred-fold improvement in the detection limit for tumour DNA. Analysis of the DNA that the tumour sheds into the bloodstream provides a non-invasive means of […]
Although it has been known that different genes determine different characteristics in male and females, new research suggests that differences in gene expression has a much larger impact than previously thought. Many diseases and traits show difference between the sexes. For example, autism is more common in males than females, but multiple sclerosis is more […]
Scientists have found that RNA production is behind the regenerative affects of laser skincare treatments. Laser treatments are a widespread cosmetic procedure to make skin appear younger and healthier. The laser slightly damages the skin cells, forcing them to repair themselves. After the repair process, the skin looks younger, but until recently the mechanism to […]
Epitranscriptomics – An Interview with Samie Jaffrey, Professor of Pharmacology, Weill Cornell Medicine
The study of epitranscriptomics has ramifications for better understanding disease symptoms and pushing forward drug treatment. But it’s also an emerging area still misunderstood by many. FLG spoke to Dr Samie Jaffrey, Professor of Pharmacology, Weill Cornell Medicine, about the field.
Fleeting genetic changes observed in stem cells as they differentiate could shed light on the origin of certain genetic diseases. Scientists studying stem cell differentiation usually only compare the differences in gene expression between the fully undifferentiated and differentiated cells. However, new research has revealed that the fleeting genetic changes during cell development could have […]
Oxford Nanopore has launched its two new “109” cDNA kits, which provide high throughput while generating complete sequences of full-length cDNA strands with a low input option of just 1ng PolyA+ RNA.
Laurent Neau, Lead Technician at the Philip Morris International Tissue Research Laboratory, talks about RNAscope®, a novel and increasingly popular technology developed by Advanced Cell Diagnostics, Inc. for the in situ analysis of RNA within fixed tissues, now optimised for use on 3D, organotypic cell cultures. Doing this has the potential to provide a window into gene expression as it occurs in the human body.
Single nucleotide variations could be the key to better identification of tumour subpopulations
Neural networks and supervised machine learning (ML) techniques can characterise cells studied using single cell RNA-sequencing (scRNA-seq), scientists from Carnegie Mellon University (CMU) have learnt. This could aid others in identifying new cell subtypes and in discerning diseased cells.