RNA

The transcriptome gives a fuller picture of how genes are expressed. RNA sequencing allows for more detailed information on cellular pathways and expression levels in cancer studies.

New Diagnostic for Coronavirus Receives CE mark

Yesterday, a test developed by Co-diagnostics for the detection of SARS-CoV-2, received CE marking as the virus nears “pandemic” status. CE-IVD marking indicates that the IVD conforms with relevant EU directives regarding the health and safety of the product.

Coronavirus Genome Now On UCSC Genome Browser

The biomolecular code of the deadly Wuhan pneumonia virus, the coronavirus, is now available to view on the UCSC Genome Browser. With nearly 41,000 cases and 910 deaths to date, the deadly virus has forced more than 50 million people to be quarantined by the Chinese government in an aim to stop the spread of the virus.

RNA Modification – A Viral Hideout

Scientists show how hMPV virus exploits RNA modification to prevent host differentiation of self and non-self RNA, thereby evading an innate immune response. This mechanism could serve as a hMPV vaccine target, and potentially more if found to be well-conserved.

Soybean Oil Can Cause Genetic Changes in the Brain

New research from the University of California, Riverside has shown that America’s most widely consumed oil – Soybean oil – can affect neurological conditions such as anxiety, depression, autism, and Alzheimer’s disease. The work builds upon previous studies that have identified a number of health risks associated with the oil, such as obesity and diabetes.

Discovering the Function of Ultra-Conserved “Poison Exons” Through a CRISPR-Based Tool

Scientists at Seattle’s Fred Hutchinson Cancer Research Centre have used a CRISPR-based tool to identify the role of ultra-conserved elements in DNA in blocking the growth of tumour cells and keeping healthy cells growing. Published in Nature Genetics, the research found the importance of these ultra-conserved elements that have remained identical between species, such as humans and mice, over millions of years and showed how essential they are in maintaining a healthy cell.

Sequencing Buyers’ Guide

Get past the hype and bias in sequencing vendor marketing materials, and get an unbiased, highly informed view from a highly qualified professional whose job it is to evaluate sequencing technologies for a world leading healthcare and research institution – the Mayo Clinic. Get a base- to high-level understanding of the sequencing process, to give […]

Huntington’s Therapy Found in Ancient Worms

A highly conserved mechanism in worms and humans has been discovered by researchers at Monash University that could provide a novel therapeutic approach for neurodegenerative diseases such as Huntington’s and Parkinson’s.

SMAUG – A Helpful Prion?

Prions are viewed as disastrous for cells; unbreakable, infectious, clumps of protein that self-propagate leading to toxic gain or loss of function. However, researchers from Stanford University have discovered a new role for prions in transmitting epigenetic information and promoting proliferation.

Telomere Gene Holds Key to Pluripotency

A gene that codes for a telomere protein is the key to regulating stem cell pluripotency, new research shows. Pluripotent stem cells have the ability to differentiate into any type of specialised cell in the body. They hold huge potential for a range of regenerative medical treatments. Scientists have previously struggled to understand the genetic […]

New Blood Test Can Predict Cancer Progression

A new technique to analyse the tumour DNA present in patient’s blood circulations is an effective method to monitor breast cancer progression. The technique has been shown to give a hundred-fold improvement in the detection limit for tumour DNA. Analysis of the DNA that the tumour sheds into the bloodstream provides a non-invasive means of […]

Gender Affects Gene Expression in Mammals

Although it has been known that different genes determine different characteristics in male and females, new research suggests that differences in gene expression has a much larger impact than previously thought. Many diseases and traits show difference between the sexes. For example, autism is more common in males than females, but multiple sclerosis is more […]

RNA Key to Anti-Ageing Skincare

Scientists have found that RNA production is behind the regenerative affects of laser skincare treatments. Laser treatments are a widespread cosmetic procedure to make skin appear younger and healthier. The laser slightly damages the skin cells, forcing them to repair themselves. After the repair process, the skin looks younger, but until recently the mechanism to […]

Fleeting Genetic Changes Could Have Lasting Impact

Fleeting genetic changes observed in stem cells as they differentiate could shed light on the origin of certain genetic diseases. Scientists studying stem cell differentiation usually only compare the differences in gene expression between the fully undifferentiated and differentiated cells. However, new research has revealed that the fleeting genetic changes during cell development could have […]