Science

Disruptive science can have a significant impact outside of our own domains of research and into our personal lives. Keeping abreast of these developments can help prepare and inspire.

Shareable Science: Beyond the Blog COVID-19

In an effort to continue keeping the public informed about COVID-19, the HudsonAlpha Institute for Biotechnology has launched a series of educational videos to help separate fact from myth about the virus. 

Interview with Dr Luigi Grassi, Informatics Scientist, AstraZeneca

FLG: Could you give us an introduction of yourself and the work you do? I’m Luigi Grassi and I’m an Informatics Scientist at AstraZeneca. I’m responsible for designing and performing bioinformatical analyses of the high throughput sequencing experiments we use to characterise stable cell lines expressing biotherapeutics. FLG: What motivated you to pursue a career […]

Shareable Science: The Genetics of Coronavirus

In early December, an outbreak of respiratory illness was reported in Wuhan, China. Scientists quickly determined the sickness was caused by a new virus from the coronavirus family. In an attempt to limit the spread of the virus, China has reacted with transportation lockdowns and public health advisories.

Coronavirus Genome Now On UCSC Genome Browser

The biomolecular code of the deadly Wuhan pneumonia virus, the coronavirus, is now available to view on the UCSC Genome Browser. With nearly 41,000 cases and 910 deaths to date, the deadly virus has forced more than 50 million people to be quarantined by the Chinese government in an aim to stop the spread of the virus.

OCD Drug Designed by Artificial Intelligence Set to Enter Clinical Trials

A new drug created with artificial intelligence (AI) to treat patients with obsessive-compulsive disorder (OCD) will be entering human clinical trials this March – a first for AI. It has cut the drug development time from four and a half years to just 12 months, accelerating the time it typically takes to develop drugs for clinical trials.

Telomere Maintenance Mutations and Cancer Cell Immortality

New research has identified mutations that could lead to the lengthening of telomeres, a hallmark of cancer cells and an important focus in developing targeted treatments. Scientists from the German Cancer Research Center looked at cancer cells to find the ways some of them achieve immortality in a study as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG).

The Cancer Drug That Could Also Fight Obesity

A cancer-fighting compound has been found to also reduce fat in obese mice and could potentially help 93 million obese Americans fight their fat. Eric Prossnitz and his team at the University of New Mexico, USA discovered that the G-1 compound currently in clinical trials for breast cancer can also reduce fat and eliminate diabetes in mice.

RNA Modification – A Viral Hideout

Scientists show how hMPV virus exploits RNA modification to prevent host differentiation of self and non-self RNA, thereby evading an innate immune response. This mechanism could serve as a hMPV vaccine target, and potentially more if found to be well-conserved.

East Asian and European Genomic Differences Found in Lung Cancer

New research from institutions in Singapore and China has identified genetic differences that occur between lung adenocarcinomas in East Asians and Europeans. Published in Nature Genetics, the researchers found that lung adenocarcinomas had more stable genomes in East Asians than in Europeans, and a stronger difference in smokers compared to non-smokers.

21 Gene Variants May be Linked to Gender Dysphoria

Gene variants that could play a role in the incongruence transgender individuals experience may have been found in the genes for oestrogen receptor pathways. Published in Nature, this study identified some of the first biological evidence that linked 21 gene variants in 19 genes with a possible role in sex-specific development during birth in an […]

Interview with Dr Halima Moncrieffe, Assistant Professor, Cincinnati Children’s Hospital Medical Center

Dr Halima Moncrieffe is an Assistant Professor at Cincinnati Children’s Hospital, ranked top 3 in the USA, where she combines genomics with immunology to understand medication response and disease etiology. Halima is an award-winning immunologist who’s ultimate goal is to move towards a cure for Juvenile Idiopathic Arthritis, so children can live pain-free and to their full potential