New research has identified a possible reason why men are more susceptible to cancer than women. The work published in the Journal of the National Cancer Institute reports that the loss of function in certain genes of the sex-determining Y chromosome may play a role in this.
The advancement of sequencing technology has had the singe biggest effect on genomics research. As it develops further, so does the scope of genomic research and applications.
A new discovery by a Japanese team has identified a type of microorganism called an Asgard archaeon, which could shed light on how early eukaryotic cells evolved. The project took 12 years after finding the cells in deep-sea mud. The findings of the closest Archaeal relative to eukaryotes cultures so far will allow further detailed cellular and metabolic investigation and find out more about the origins of complex life.
An international team of researchers has assembled a human genome using just the remnants of a piece of birch tar—last chewed some 5,700 years ago. Scientists have pieced together quite a bit about the person’s life using DNA left in the tar, learning about everything from her diet to certain diseases she carried.
Dozens of rare DNA variants have been identified in the largest genetic study of human height in an Asian population. The genome-wide association study (GWAS) highlighted some of the similarities and differences that play a role in determining height in different parts of the world.
A genome-wide analysis of nearly 200,000 military veterans has identified six genetic variants linked to anxiety. This is the largest genome-wide association study (GWAS) to date, and has given insights into how people may be pre-disposed to anxiety disorders and provides further explanations for why anxiety and depression often coexist.
A collaborative fine-mapping study from researchers across more than 450 departments worldwide has found five times more genetic variants to be associated with breast cancer than previously thought. The most comprehensive map of breast cancer risk variants to date identified 352 DNA errors that are associated with breast cancer with “reasonable confidence”, and target 191 genes, five times more than were previously recognised.
Scientists at Seattle’s Fred Hutchinson Cancer Research Centre have used a CRISPR-based tool to identify the role of ultra-conserved elements in DNA in blocking the growth of tumour cells and keeping healthy cells growing. Published in Nature Genetics, the research found the importance of these ultra-conserved elements that have remained identical between species, such as humans and mice, over millions of years and showed how essential they are in maintaining a healthy cell.
Get past the hype and bias in sequencing vendor marketing materials, and get an unbiased, highly informed view from a highly qualified professional whose job it is to evaluate sequencing technologies for a world leading healthcare and research institution – the Mayo Clinic. Get a base- to high-level understanding of the sequencing process, to give […]
Illumina, Inc. (Illumina) and Pacific Biosciences of California, Inc. (PacBio) announced that they have mutually agreed to terminate their merger agreement. The merger was first proposed in November 2018 that Illumina would be acquiring PacBio at a fully diluted enterprise value of ~$1.2 billion. Now with the merger terminated, Illumina will have to pay a termination fee of $98 million to PacBio.
Genetic and genomic testing has been a hot topic in the healthcare industry in recent years. The NHS has introduced a Genomic Medicine Service (GMS) in an aim to ensure equitable access to genetic and genomic testing and integrate this into routine NHS care by 2025, driving more personalised treatments for patients in the process.
In southern Denmark, researchers excavated a lump of ancient chewing gum made from birch tar from a shallow lagoon. A young woman living around 5,700 years ago had discarded her gum which was recently found among pieces of wood and wild animal bone during an archaeological excavation.
When considering the clinical applications of computational genomics, the true challenge stems from both the nature of the processed genomic data and the purpose behind processing it. The clinical context renders analyses useful only if their results meet rigorously defined standards and can be provided on time. Scalability to tens of thousands of samples is […]
George Church of Harvard University has been under heavy scrutiny after news broke out of a new “DNA Dating App” he has been involved in developing, during a recent interview with 60 minutes. The news has led to a significant backlash from some quarters, including from some within the genomics community, that the app is unethical and represents a form of eugenics.
Scientists are all about new discoveries. As it turns out, we get especially excited when those “new discoveries” are thousands of years old. Researchers in Russia recently unveiled an 18,000-year-old puppy that was preserved in permafrost. The animal is somewhere between a wolf and a dog, and that ambiguity speaks to the oft-pondered mystery of how the two species diverged.
Novel genes associated with the peanut allergy severity and the way the genes interact together have been identified by researchers at the Icahn School of Medicine at Mount Sinai. The findings from this study could lead to the development of better treatments and approaches to identify biomarkers that can predict the severity of a peanut allergy before exposure.